%0 Journal Article
%T Research: FORMULATION AND EVALUATION OF CHITOSAN NANOSPHERES AS A CARRIER FOR THE TARGETED DELIVERY OF LAMIVUDINE TO THE BRAIN
%A Dhanya K P*
%A K Santhi
%A S A Dhanaraj
%A C I Sajeeth
%J Pharmacie Globale : International Journal of Comprehensive Pharmacy
%D 2011
%I 
%X The present study deals with the formulation and evaluation of surfactant coated and uncoated chitosan nanospheres containing Lamivudine for the targeted delivery to the brain. Nanospheres were prepared by a modified spontaneous emulsification method and different process variables were optimized. 0.5 % of chitosan gel and 2.5ml of gluteraldehyde saturated toluene per 25mg of polymer were selected as the optimum concentrations of polymer and cross linking agent, which yielded nanospheres of discrete nature, with an average size range of 154.99- 187.01nm. There was a proportional relationship between the drug loading capacity and drug concentration up to a concentration of 20mg drug /50mg of polymer, thereafter, an inverse relationship was observed. FT-IR studies indicated that there was no chemical interaction between the drug and polymer. The in-vitro release behavior from all the drug loaded batches was found to be biphasic with an initial burst release followed by a sustained release over a period of 24hr. Surfactant coated nanospheres were prepared by adsorption method, the in-vitro release study of which showed a delay in the initial burst release. Mechanism by which the drug is being released was found to be a non- Fickian analomous diffusion, and the drug release was followed by first order kinetics. The drug loaded batches showed good stability when stored at room temperature for 60 days. Hence the formulated Tween 80 coated nanospheres can be used as an alternative and cheaper carrier for the targeted delivery of Lamivudine to the brain, especially for the treatment of HIV associated CNS disorders like AIDS dementia.
%K Lamivudine
%K chitosan nanoparticles
%K AIDS dementia
%K Blood Brain Barrier
%K Antiretroviral therapy.
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