%0 Journal Article
%T H赤gado graso: Enfoque diagn車stico y terap谷utico Fatty liver: Diagnostic and therapeutic approach
%A Alfredo Herrera Gonz芍lez
%A Alfredo Nasiff Hadad
%A Enrique Arus Soler
%A Cosme Cand Huerta
%J Revista Cubana de Medicina
%D 2007
%I ECIMED
%X El enfoque diagn車stico y terap谷utico que se propusieron en esta revisi車n sobre "h赤gado graso" se hizo en funci車n de las necesidades del m谷dico pr芍ctico. Se plante車 una disquisici車n te車rica sobre el problema terminol車gico de este s赤ndrome y se abordaron los mecanismos patog谷nicos comunes en las diferentes condiciones cl赤nicas que predisponen a padecer este problema de salud que puede presentarse como una simple esteatosis hep芍tica, pero tambi谷n puede llegar a ser causa de una cirrosis hep芍tica que conduzca al paciente a un transplante hep芍tico. Se consider車 la importancia de sopesar la suma de factores que predisponen a la enfermedad, los estudios imagenol車gicos y marcadores de riesgo de desarrollo de fibrosis antes de indicar la biopsia hep芍tica. El tratamiento va dirigido a disminuir el flujo de 芍cidos grasos al h赤gado, proteger al hepatocito de mecanismos oxidativos, evitar t車xicos conocidos que da en al h赤gado y tratar los factores condicionantes o asociados. Se propuso un algoritmo de atenci車n y seguimiento de estos enfermos. The diagnostic and therapeutic approach on ※fatty liver§, proposed in this review, was made to meet the needs of the practitioner. A theoretical disquisition on the terminological problem of this syndrome was stated, and the common pathogenic mechanisms in the different clinical conditions predisposing to suffer from this health problem, that may appear as a simple hepatic steatosis, but that may also be the cause of liver cirrhosis leading the patient to a liver transplantation, were approached. It was considered the importance of hefting the sum of the factors predisposing the disease, the imaging studies, and the risk markers of the development of fibrosis before indicating the liver biopsy. The treatment is intended to reduce the flow of fatty acids to the liver, to protect the hepatocyte from oxidative mechanisms, to avoid known toxic agents damaging the liver, and to treat the conditioning or associated factors. An algorithm of care and follow-up of these patients was suggested.
%K Enfermedad grasa no alcoh車lica del h赤gado
%K esteatosis simple
%K esteatohepatitis
%K enfermedad metab車lica.
%K Non-alcoholic fatty liver disease
%K simple esteatosis
%K esteatohepatitis
%K metabolic disease
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232007000100009