%0 Journal Article
%T Neuropat赤a auton車mica en la drepanocitosis y su relaci車n con la amiloidosis sist谷mica Autonomic neuropathy in sickle cell disease and its relationship to systemic amyloidosis
%A Adalberto Fort迆n Prieto
%A Adalberto Fort迆n Campo
%A Mirta Caridad Campo D赤az
%A Mar赤a Victoria L車pez Delcourt
%J Revista Cubana de Medicina
%D 2010
%I ECIMED
%X Se realiz車 el estudio de la funci車n auton車mica a 25 pacientes con drepanocitosis mediante el an芍lisis de la tensi車n arterial continua durante la maniobra de Valsalva, y las variaciones de la frecuencia card赤aca y la tensi車n arterial en la posici車n ortost芍tica con el objetivo de identificar la presencia en ellos de disautonom赤a. Previamente, se hab赤a determinado la existencia de amiloidosis sist谷mica mediante biopsia por aguja fina de la grasa abdominal para evaluar si su presencia se relaciona con dicha anomal赤a neurol車gica. La amiloidosis estuvo presente en el 60 % de los pacientes y la afectaci車n del sistema nervioso aut車nomo predominante fue la ca赤da de la tensi車n arterial sist車lica durante el ortostatismo as赤 como el 赤ndice VS-IIA/IIB mayor de 60 %, lo que constituye un indicador de disfunci車n simp芍tica. Se concluy車 que la presencia de amiloidosis no guard車 relaci車n significativa con la disfunci車n neurol車gica vegetativa encontrada. We studied autonomic function in 25 patients with sickle cell disease through the analysis of continuous blood pressure during Valsalva maneuver, and changes in heart rate and blood pressure in the standing position in order to identify the presence of dysautonomy in them. The existence of systemic amyloidosis had been previously determined by fine needle biopsy of abdominal fat to determine whether its presence is related to such neurological abnormality. Amyloidosis was present in 60 % of the patients and the predominant autonomic nervous system involvement was the fall in systolic blood pressure during orthostatism, as well as a VS-IIA/IIB index greater than 60 %, which is an indicator of sympathetic dysfunction. It was concluded that the presence of amyloidosis was not significantly related to the vegetative neurological dysfunction found.
%K Drepanocitosis
%K neuropat赤a auton車mica
%K amiloidosis
%K Sickle cell disease
%K autonomic neuropathy
%K amyloidosis
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75232010000300004