%0 Journal Article
%T Efectos hemodin芍micos de la supresi車n del propranolol en ratas
%A Manuel Chaple La Hoz
%A Ernesto Barber Guti谷rrez
%A Wilfrido Rom芍n Aldama
%A Jos谷 Castillo Herrera
%J Revista Cubana de Investigaciones Biomˋˋdicas
%D 1996
%I ECIMED
%X Se estudia el efecto de la supresi車n del tratamiento con propranolol (0,5 mg/100 g rata/d赤a) en soluci車n acuosa, sobre la volemia y otras variables hemodin芍micas en 20 ratas blancas. Paralelamente se llevaron 20 controles a los que se les administr車 agua destilada. La presi車n arterial sist車lica se midi車 a los 20 d赤as del tratamiento y a los 20 y 45 d赤as de supresi車n de 谷ste. A los 45 d赤as de supresi車n de la droga a un subgrupo de 10 se le midi車 la volemia, utilizando como sustancia indicadora el Azul de Evans. Al otro subgrupo se le midi車 la presi車n arterial media, presi車n circulatoria media y presi車n venosa central en un pol赤grafo de 4 canales. Como resultado se obtuvo un aumento significativo del volumen sangu赤neo, volumen de plasma y frecuencia card赤aca, y un aumento altamente significativo de la presi車n arterial media, presi車n arterial sist車lica, presi車n venosa central y circulatoria media. De acuerdo con estos resultados se concluye que la supresi車n del propranolol provoca retenci車n hidrosalina producto de hipertrofia tubular, lo cual pudiera esclarecer a迆n m芍s el papel del ri 車n en la hipertensi車n arterial esencial. The effect of the suppression of the treatment with propranolol (0,5 mg/100 g rat/day) in aquous solution on blood volume and other hemodynamic variables was studied in 20 white rats. At the same time 20 con-trols were carried out to which distilled water was administered. The systolic arterial pressure was measured 20 days after the beginning of treatment, and 20 and 45 days after its suppression. 45 days after the drug's suppression, blood volume was measured in a subgroup of ten, using Evans' blue as an indicator substance. Mean arterial pressure, mean circulatory pressure, and central venous pressure were measured in the other subgroup by using a 4-channel polygraph. As a result, a marked increase of blood volume, plasma volume, and heart frequency was obtained. A highly significant rise of mean arterial pressure, systolic arterial pressure, central venous pressure, and mean circulatory pressure was also observed. According to the results, it is concluded that propranolol's suppression causes hydrosaline retention resulting from tubular hypertrophy, which could make even more clear the role of kidney in essential arterial hypertension.
%K PROPRANOLOL
%K RATAS
%K HEMODINAMICA
%K PRESION SANGUINEA
%K PROPRANOLOL
%K RATS
%K HEMODYNAMICS
%K BLOOD PRESSURE
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03001996000200003