%0 Journal Article
%T Comportamiento de la peroxidaci車n lip赤dica en la insuficiencia renal cr車nica
%A Ana A. Rodr赤guez Alban谷s
%A Eva Barranco Hern芍ndez
%A Celia A. Alonso Rodr赤guez
%A Josanne Soto Matos
%J Revista Cubana de Investigaciones Biomˋˋdicas
%D 2003
%I ECIMED
%X Se evalu車 el estr谷s oxidativo en 87 pacientes con insuficiencia renal cr車nica en diferentes estadios, conocido el desequilibrio qu赤mico que ocasiona la peroxidaci車n lip赤dica y su demostrada presencia en la uremia; se determin車 la peroxidaci車n lip赤dica por medio del malonildialdeh赤do intraeritrocitario, con el m谷todo de las sustancias reactivas la 芍cido tiobarbit迆rico. La poblaci車n fue dividida en grupos para su estudio: predi芍lisis, di芍lisis peritoneal, hemodi芍lisis y un grupo control. A todos se les determin車 hemat車crito, creatinina, colesterol, triglic谷ridos y malonildialdeh赤do intraeritrocitario. Los pacientes con insuficiencia renal cr車nica tuvieron niveles elevados de malonildialdeh赤do intraeritrocitario con respecto al control. El an芍lisis estad赤stico de los resultados corrobor車 la relaci車n entre el aumento de la peroxidaci車n lip赤dica y el avance del da o renal. El grupo hemodi芍lisis con valor m芍s alto de malonildialdeh赤do intraeritrocitario, present車 los m芍s bajos de l赤pidos, lo que implica independencia de estos. Se demostr車 que los pacientes renales cr車nicos est芍n sometidos al estr谷s oxidativo desde etapas tempranas de la enfermedad, factor que interviene probablemente en la anemia multicausal, que induce hem車lisis oxidativa la cual ocasiona la disrupci車n de las membranas, donde desempe a un papel importante el proceder dial赤tico. Known the chemical unbalance produced by lipid peroxidation (LP) and its proved presence in uremia, the oxidative stress was evaluated in 87 patients with chronic kidney failure (CKF) at different stages, determining the LP by means of the intraerythrocytic malonyldialdehyde (E-MDA) with the thiobarbituric acid reactive substances method (TBARS). The population was divided into groups for its study: predialysis, peritoneal dialysis, hemodialysis and a control group. Hematocrit, creatinine, cholesterol, triglycerides and E-MDA were determined in all patients. Those patients with chronic kidney failure had elevated levels of E-MDA compared with the contol group. The statistical analysis of the results corroborated the relation between the increase of LP and the advance of the kidney damage. The hemodialysis group with the highest value of E-MDA presented the lowest lipid levels, which shows the independence of them. It was proved that chronic kidney patients are subjected to oxidative stress since early stages of the disease, a factor that probably takes part in multicausal anemia, inducing oxidative hemolysis, which brings about the disruption of the membranes, where the dialytic procedure plays an important role.
%K PEROXIDACION DE LIPIDO
%K UREMIA
%K INSUFICIENCIA RENAL CRONICA
%K ESTRES OXIDATIVO
%K RADICALES LIBRES
%K HEMODIALISIS
%K LIPID PEROXIDATION
%K UREMIA
%K KIDNEY FAILURE
%K CHRONIC
%K OXIDATIVE STRESS
%K FREE RADICALS
%K HEMODIALYSIS
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002003000100002