%0 Journal Article
%T Stability of Recombinant Tissue Plasminogen Activator at £¿30 ¡ãC over One Year
%A Abdulmalik Alkatheri
%J Pharmaceuticals
%D 2013
%I MDPI AG
%R 10.3390/ph6010025
%X Recombinant tissue plasminogen activator (rt-PA) is used to restore patency and avoid inadvertent removal of peripheral and central venous catheters. rt-PA was reconstituted (1 mg/mL) then cryopreserved at £¿30 ¡ãC for 1, 2, 3, 6, 8, and 12 months and, then its stability was determined. After cryopreservation for one and two months, rt-PA kept more than 95% of its activity compared to standard samples, while cryopreservation for three months caused 8% loss of activity. However, after cryopreservation for six months or more, rt-PA retained only 87.5% or less activity compared to standard samples. Therefore, it is recommended that reconstituted rt-PA be cryopreserved at £¿30 ¡ãC for a maximum period of three months.
%K cryopreservation
%K fibrinolysis
%K stability
%K tissue plasminogen activator
%U http://www.mdpi.com/1424-8247/6/1/25