%0 Journal Article
%T Aproximaci¨®n al cultivo de condrocitos en la Universidad Nacional de Colombia.: Reporte t¨¦cnico Approach to chondrocytes culture in National University of Colombia.: A technical report
%A Nancy Stella Land¨ªnez Parra
%A Diego Alexander Garz¨®n Alvarado
%A Carmen Alicia Cardozo de Mart¨ªnez
%J Revista Cubana de Investigaciones Biom£¿£¿dicas
%D 2010
%I ECIMED
%X La p¨¦rdida de un tejido o de su funci¨®n, debido a defectos cong¨¦nitos, enfermedad o trauma, es uno de los problemas m¨¢s dif¨ªciles, frecuentes y costosos que enfrenta la medicina humana. La degeneraci¨®n del cart¨ªlago articular se conoce como osteoartrosis (OA), la cual se manifiesta mediante da o enzim¨¢tico y mec¨¢nico de la matriz extracelular, que genera dolor y conduce a p¨¦rdida del movimiento e inestabilidad articular. El cart¨ªlago articular tiene una baja capacidad de reparaci¨®n, por su avascularidad. El presente trabajo pretende realizar una aproximaci¨®n a la ingenier¨ªa tisular del cart¨ªlago con el prop¨®sito de establecer la fundamentaci¨®n te¨®rica en el tema para comprender el comportamiento in vitro del tejido que permita a futuro construir un equivalente de cart¨ªlago mediante los procedimientos actuales de ingenier¨ªa tisular, que ofrezca respuesta a la problem¨¢tica social y de salud p¨²blica. Las conclusiones del presente trabajo posibilitan futuras investigaciones en el campo de la regeneraci¨®n de cart¨ªlago articular y su aplicaci¨®n cl¨ªnica e igualmente brindan las bases para plantear investigaciones in vivo o in vitro que profundicen en el tema. The loss of a tissue or its function due to congenital defects, disease or trauma, is one of the major, frequent and expensive problems challenging the human medicine. The articular cartilage degeneration is known as osteoarthritis (OA), which is characterized by enzyme and mechanical damage of extracellular matrix, generating pain and lead to the loss of movement and articular instability. The articular cartilage has low repair ability due to its avascularization. The aim of present paper is to make an approach to cartilage tissue engineering to establish the theoretical basis on this subject to understand the tissue in vitro behavior allowing in the future, to construct a cartilage equivalent by means of current procedures of tissue engineering, offering a response to social problems and of the public health. Conclusions from present paper make easy futures researches in the field of articular cartilage regeneration and its clinical application and also, providing the bases to planning in vivo and in vitro researches to deepen in this subject.
%K cart¨ªlago articular
%K ingenier¨ªa tisular
%K condrocitos
%K factores de crecimiento
%K bioreactores
%K Articular cartilage
%K tissue engineering
%K chondrocytes
%K growth factors
%K bioreactors
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002010000100006