%0 Journal Article
%T Glutathione Transferase (GST)-Activated Prodrugs
%A Paolo Ruzza
%A Andrea Calderan
%J Pharmaceutics
%D 2013
%I MDPI AG
%R 10.3390/pharmaceutics5020220
%X Glutathione transferase (formerly GST) catalyzes the inactivation of various electrophile-producing anticancer agents via conjugation to the tripeptide glutathione. Moreover, several data link the overexpression of some GSTs, in particular GSTP1-1, to both natural and acquired resistance to various structurally unrelated anticancer drugs. Tumor overexpression of these proteins has provided a rationale for the search of GST inhibitors and GST activated cytotoxic prodrugs. In the present review we discuss the current structural and pharmacological knowledge of GST-activated cytotoxic compounds.
%K glutatione transferase
%K glutathione
%K anticancer prodrugs
%U http://www.mdpi.com/1999-4923/5/2/220