%0 Journal Article
%T Efecto del extracto hipoglicemiante de Petiveria alliacea L sobre el consumo de glucosa por los eritrocitos
%A Delia Rojo Dom赤nguez
%A Luis Bell Heredia
%A Elena Cancio Mart赤nez
%A Roberto Iglesias Lores
%J Revista Cubana de Investigaciones Biomˋˋdicas
%D 2002
%I ECIMED
%X Se estudi車 el efecto de un extracto hipoglicemiante de Petiveria alliacea L sobre el consumo de glucosa por los eritrocitos de donantes voluntarios sanos. Los eritrocitos se incubaron con una diluci車n de sheilina de 1 UD/10 mL durante 4 h y se determin車 la concentraci車n de glucosa a los tiempos 0, 30, 60, 90, 120, 150, 180, 210 y 240 min. Para determinar si hab赤a efecto dosis respuesta se incubaron los eritrocitos con dosis crecientes de sheilina (0, 0,5, 1, 5, 10 y 15 U/10 mL). Se obtuvo que la sheilina no afecta el consumo de glucosa por los eritrocitos ni a dosis elevadas. Estos resultados sugieren que la acci車n del producto no afecta el transportador de glucosa (glut 1) ni la fase anaerobia de la glic車lisis, por lo que su acci車n hipoglicemiante parece estar ligada a la acci車n de la insulina. The effect of a hypoglycemic extract of Petiveria alleacea L on glucose consumption was studied by using the erythrocytes of voluntary healthy donors. The erythrocytes were incubated with a dilution of sheilina of 1 UD/10 mL during 4 hours and the glucose concentration was determined at 0, 30, 60, 90, 120, 150, 180, 210 and 240 min. To determine the existance of a dose response effect, the erythrocytes were incubated with increasing doses of sheilina (0, 0.5, 1, 5, 10 and 15 U/10 mL) It was observed that even at elevated doses sheilina does not affect the consumption of glucose by the erythrocytes. These results suggest that the action of the product affects neither the glucose tansporter (glut 1) nor the anaerobic phase of glycosis. That＊s why its hypoglycemic action seems to be connected with insulin action.
%K PLANTAS MEDICINALES
%K EXTRACTOS VEGETALES
%K ERITROCITOS
%K DIABETES MELLITUS
%K DIABETES MELLITUS
%K AGENTES HIPOGLUCEMICOS
%K PLANTS
%K MEDICINAL
%K PLANT
%K EXTRACTS
%K ERYTHROCITES
%K DIABETES MELLITUS
%K DIABETES MELLITUS
%K HYPOGLYCEMIC AGENTS
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002002000300003