%0 Journal Article
%T A Potent (R)-alpha-bis-lipoyl Derivative Containing 8-Hydroxyquinoline Scaffold: Synthesis and Biological Evaluation of Its Neuroprotective Capabilities in SH-SY5Y Human Neuroblastoma Cells
%A Ivana Cacciatore
%A Erika Fornasari
%A Leonardo Baldassarre
%A Catia Cornacchia
%A Stefania Fulle
%A Ester Sara Di Filippo
%A Tiziana Pietrangelo
%A Francesco Pinnen
%J Pharmaceuticals
%D 2013
%I MDPI AG
%R 10.3390/ph6010054
%X A novel bis-lipoyl derivative containing 8-hydroxyquinoline scaffold (LA-HQ-LA, 5) was synthesized as a new multifunctional drug candidate with antioxidant, chelant, and neuroprotective properties for the treatment of neurodegenerative diseases. We have investigated the potential effectiveness of LA-HQ-LA against the cytotoxicity induced by 6-OHDA and H2O2 on human neuroblastoma SH-SY5Y cell line. Our outcomes showed that LA-HQ-LA resulted in significant neuroprotective and antioxidant effects against H2O2- and 6-OHDA-induced neurotoxicity in human neuroblastoma SH-SY5Y cells, as assessed by MTT assay. In particular, it showed potent neuroprotective effects against 6-OHDA in RA/PMA differentiated cells at all the tested concentrations.
%K (R)-alpha-lipoic acid
%K 8-hydroxyquinoline
%K neuroprotective agent
%K antioxidants
%K neurodegenerative diseases
%U http://www.mdpi.com/1424-8247/6/1/54