%0 Journal Article
%T Lipoprote¨ªna (a): estructura, metabolismo, gen¨¦tica y mecanismos patog¨¦nicos
%A L¨¢zaro E. Alba Zayas
%A Giovanna Pereira Roca
%A Ar¨ªstides Aguilar Betancourt
%J Revista Cubana de Investigaciones Biom£¿£¿dicas
%D 2003
%I ECIMED
%X Se establecieron las caracter¨ªsticas m¨¢s sobresalientes de la lipoprote¨ªna (a), as¨ª como los mecanismos patog¨¦nicos de esta part¨ªcula lipoprote¨ªnica relacionados con la aterotrombog¨¦nesis. La lipoprote¨ªna (a) [Lp (a)], descubierta por Kare Berg en 1963, posee una composici¨®n similar a la de la lipoprote¨ªna de baja densidad (LDL). En su estructura tambi¨¦n presenta a la apolipoprote¨ªna (a) [apo (a)], la cual est¨¢ unida a la apo B100 mediante un enlace disulfuro. El aspecto m¨¢s interesante de la biolog¨ªa de la Lp (a) lo constituye, sin dudas, la sorprendente homolog¨ªa estructural que existe entre el plasmin¨®geno y la apo (a); esta apolipoprote¨ªna, adem¨¢s, es la responsable de las propiedades metab¨®licas y bioqu¨ªmicas de la lipoprote¨ªna (a). Por su estructura peculiar y la correlaci¨®n existente entre los niveles elevados de la Lp (a) y el desarrollo de complicaciones aterotromb¨®ticas, esta lipoprote¨ªna se ha convertido en el objeto de numerosas investigaciones. The most outstanding characteristics of lipoprotein (a) as well as the pathogenic mechansism of this lipoproteinic particle related to atherothrombogenesis are established. Liopoprotein (a) [Lp (a)] discovered by Kare Berg, in 1963, has a similar composition to that of low density lipoprotein (LDL). In its structure it also presents apolipoprotein (a) [apo (a)], which is bound to apo B100 by a disulfur bond. The most interesting aspect of the biology of Lp (a) is undoubtedly the surprising structural homology existing between plasminogen and apo (a). This apolipoprotein is also the responsible for the metabolic and biochemical properties of lipoprotein (a). Due to its peculiar structure and to the correlation existing between the elevated levels of Lp (a) and the development of atherothrombotic complications, this lipoprotein has become the object of numerous researches.
%K LIPOPROTEINA (a)
%K LIPOPROTEINA (a)
%K LIPOPROTEINA (a)
%K POLIMORFISMO (GENETICA)
%K APO LIPOPROTEINAS (a)
%K ATEROSCLEROSIS
%K FACTORES DE RIESGO
%K LIPOPROTEIN (a)
%K LIPOPROTEIN (a)
%K LIPOPROTEIN (A)
%K POLYMORPHISM (GENETICS)
%K APO LIPOPROTEIN (A)
%K ATHEROSCLEROSIS
%K RISK FACTORS
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-03002003000100005