%0 Journal Article
%T CD4 T-Cell-Independent Antibody Response Reduces Enterovirus 71 Lethality in Mice by Decreasing Tissue Viral Loads
%A Li-Chiu Wang
%A Chia-Min Kao
%A Pin Ling
%A Ih-Jen Su
%A Tung-Miao Chang
%A Shun-Hua Chen
%J Clinical and Developmental Immunology
%D 2012
%I Hindawi Publishing Corporation
%R 10.1155/2012/580696
%X Enterovirus 71 (EV71) has induced fatal encephalitis in hundreds of thousands of infants and young children in the Asia-Pacific region since the past decade. Lymphocyte and antibody responses have been suspected to aggravate EV71-induced neurological symptoms, so anti-inflammatory agents have been used to treat patients with neurological symptoms. In the present study, we found that mice deficient in CD4
%U http://www.hindawi.com/journals/cdi/2012/580696/