%0 Journal Article
%T Resinas de intercambio i車nico para prolongar la liberaci車n de los f芍rmacos
%A H谷ctor M Alfonso Zerquera
%A Graciela P谷rez Ramos
%A Irina D赤az Alfonso
%A Susana Alba Delgado
%J Revista Cubana de Farmacia
%D 2000
%I ECIMED
%X Se realiz車 el estudio de las resinas de intercambio i車nico como sistemas para liberaci車n prolongada con atenci車n a los factores que afectan la formaci車n de los resinatos o complejos f芍rmacoresina. Tambi谷n se estudi車 la liberaci車n de los principios activos a partir de los complejos y de las formas terminadas que los contienen, evalu芍ndose los factores que afectan dicho proceso y las cin谷ticas a las que se ajusta. Se revisaron las combinaciones de procesos tecnol車gicos (principalmente la formaci車n de complejos i車nicos y su recubrimiento) que potencian la utilidad de los resinatos para prolongar la liberaci車n a trav谷s de mecanismos combinados de intercambio i車nico y difusi車n a trav谷s de membranas, combinaciones dirigidas a reducir las limitaciones inherentes a cada proceso por separado y conseguir un control eficaz de la liberaci車n de f芍rmacos i車nicos. The study of the ion exchange resins as systems for the prolonged release was conducted, making emphasis on the factors affecting the formation of resinates or drug-resin complexes. The release of the active principles was also studied starting from the complexes and the finished forms containing them. The factors affecting this process and the kinetics to which it is adjusted were evaluated, too. The combinations of technological processes (mainly the formation of ion complexes and their coating) potentiating the usefulness of resinates to prolong the release by combined mechanisms of ion exchange and difussion through membranes, combinations directed to reduce the limitations inherent to each process separately and to achieve an efficient control of the release of ion drugs, were reviewed.
%K RESINAS DE INTERCAMBIO IONICO
%K INTERCAMBIO IONICO
%K TECNOLOGIA FARMACEUTICA
%K COMPOSICION DE MEDICAMENTOS
%K ION EXCHANGE RESINS
%K ION EXCHANGE
%K TECHNOLOGY
%K PHARMACEUTICAL
%K DRUG COMPOUNDING.
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152000000300007