%0 Journal Article
%T Vaccination and Infection as Causative Factors in Japanese Patients With Rasmussen Syndrome: Molecular Mimicry and HLA Class I
%A Yukitoshi Takahashi
%A Kazumi Matsuda
%A Yuko Kubota
%A Jiro Shimomura
%A Etsuko Yamasaki
%A Tatsuya Kudo
%A Katsuyuki Fukushima
%A Hitoshi Osaka
%A Noriyuki Akasaka
%A Atsushi Imamura
%A Shinji Yamada
%A Naomi Kondo
%A Tateki Fujiwara
%J Clinical and Developmental Immunology
%D 2006
%I Hindawi Publishing Corporation
%R 10.1080/17402520600589522
%X Rasmussen syndrome is an intractable epilepsy with a putative causal relation with cellular and humoral autoimmunity. Almost half of the patients have some preceding causative factors, with infections found in 38.2%, vaccinations in 5.9% and head trauma in 8.9% of Japanese patients. In a patient with seizure onset after influenza A infections, cross-reaction of the patient's lymphocytes with GluRε2 and influenza vaccine components was demonstrated by lymphocyte stimulation test. Database analyses revealed that influenza A virus hemagglutinin and GluRε2 molecules contain peptides with the patient's HLA class I binding motif (HLA ࢤ A*0201). The relative risks of HLA class I genotypes for Rasmussen syndrome are 6.1 (A*2402), 6.4 (A*0201), 6.3 (A*2601) and 11.4 (B*4601). The relative risks of HLA class I-A and B haplotypes are infinity (A*2601
%U http://www.hindawi.com/journals/cdi/2006/872092/abs/