%0 Journal Article
%T Cryptococcal Antigenemia in Anti-Retroviral Na ve AIDS Patients: Prevalence and Its Association with CD4 Cell Count
%A Oghomwen Favour Osazuwa
%A Osilume Dirisu
%A Evbaguehita Okuonghae
%J Acta Medica Iranica
%D 2012
%I Tehran University of Medical Sciences
%X Cryptococcus neoformans is the most incriminated fungal pathogen causing meningitis in acquired immune deficiency syndrome (AIDS) patients, and is known to constitute a major cause of deaths in AIDS patients. This study aimed to determine the sero-prevalence and effect of CD4 count on seropositivity for Cryptococcus neoformans antigen (crag) in antiretroviral- na ve (ART-na ve) AIDS patients. This study included 150 (61 males and 89 females) ART-na ve AIDS patients attending the Human Immunodeficiency Virus (HIV) clinic of the University of Benin teaching hospital, Benin City, Nigeria within the period February 2011- July 2011. 40 (18 males and 22 females) HIV positive outpatients with CD4 counts >200 cells/¦Ìl who are ART-naive were recruited and used as controls. The prevalence of crag in the patients and control group was determined using the cryptococcal antigen latex agglutination system (CALAS) (Meridian Bioscience, Europe) and CD4 counts were measured using flow cytometry (Partec flow cytometer, Germany). Of 150 ART-na ve AIDS patients with CD4 counts ¡Ü 200 cells/¦ÌL, 19 (12.7%) were positive for serum Cryptococcal antigen. ART-na ve AIDS patients with CD4 count ¡Ü50 cells/¦Ìl had the highest prevalence of serum crag. Lower CD4 counts were significantly associated with positivity for serum crag (P<0.001). Age and Sex had no significant effect on the sero-positivity for serum crag. 1 (2.5%) of the control was sero-positive for crag. Serum crag was significantly associated with AIDS but not with HIV (P<0.001). This study uncovers a high prevalence of crag in ART-na ve AIDS patients in Benin City. There is an urgent need to introduce early and routine screening for crag in ART-na ve AIDS patients for prompt intervention.
%K Cryptococcal Antigen
%K ART-Na ve AIDS Patients
%K Sero-Prevalence
%K CD4 Counts
%U http://journals.tums.ac.ir/PdfMed.aspx?pdf_med=/upload_files/pdf/20933.pdf&manuscript_id=20933