%0 Journal Article
%T Comparaci¨®n de la actividad de 2 factores estimuladores de colonias de granulocitos de producci¨®n nacional: Hebervital y Leukocim Comparison of the activity of 2 domestic- production factors for granulocyte colonies: Hebervital and Leukocim
%A Bertha Beatriz Socarr¨¢s Ferrer
%A Consuelo Mac¨ªas Abraham
%A L¨¢zaro del Valle P¨¦rez
%A Vianed Mars¨¢n Su¨¢rez
%J Revista Cubana de Hematolog£¿-a, Inmunolog£¿-a y Hemoterapia
%D 2011
%I Editorial Ciencias M¨¦dicas
%X En 35 pacientes que deb¨ªan recibir terapia celular regenerativa se evalu¨® el efecto estimulante de 2 factores estimuladores de colonias de granulocitos de producci¨®n cubana: Hebervital y Leukocim, para la movilizaci¨®n de c¨¦lulas madre hematopoy¨¦ticas hacia la sangre perif¨¦rica. Los pacientes se seleccionaron de forma aleatoria en 2 grupos de tratamiento y se les suministr¨® por v¨ªa subcut¨¢nea una dosis total de 40 mg/kg distribuidos en 4 subdosis de 10 mg/kg administrados cada 12 horas. Se realiz¨® el conteo de las c¨¦lulas mononucleares y c¨¦lulas CD34+ en sangre perif¨¦rica mediante citometr¨ªa de flujo, antes y despu¨¦s de la estimulaci¨®n. No se encontraron diferencias estad¨ªsticamente significativas en los conteos de las c¨¦lulas CD34+ obtenidas posestimulaci¨®n con el Hebervital y el Leukocim. In 35 patients who should have received regenerative cell therapy, it was evaluated the effect of 2 domestic production granulocyte colony stimulating factors: Leukocim and Hebervital for the mobilization of hematopoietic stem cells into peripheral blood. Patients were randomly selected into 2 treatment groups and were given a total dose of 40 mg/kg in 4 sub-doses of 10 mg/kg subcutaneously administered every 12 hours. Count was performed for mononuclear cells and CD34+ cells in peripheral blood by flow cytometry before and after stimulation. There were no statistically significant differences in the counts of CD34+ cells obtained after stimulation with Hebervital and Leukocim.
%K Factor estimulador de colonias de granulocitos
%K FEC-G
%K c¨¦lulas CD34
%K c¨¦lulas mononucleares
%K Granulocyte colony stimulating-factor
%K G-CSF
%K CD34+ cells
%K mononuclear cells
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864-02892011000400007