%0 Journal Article
%T Evaluaci車n de una zeolita natural modificada y decolorada como antimicrobiano
%A Iliana Perdomo L車pez
%A Zulia Weng Alem芍n
%A Dania Montero Garnache
%A Antonio Iraizoz Colarte
%J Revista Cubana de Farmacia
%D 1999
%I ECIMED
%X Se desarroll車 una metodolog赤a para la decoloraci車n de una zeolita natural modificada con la utilizaci車n de 芍cido ortofosf車rico al 100 %. Se le realiz車 al producto obtenido un control qu赤mico, el cual no present車 cambios en su estructura por la decoloraci車n, lo que se corrobor車 mediante la determinaci車n de su actividad antimicrobiana in vitro frente a cepas microbianas grampositivas y gramnegativas, as赤 como Candida albicans. Se comporb車 que la concentraci車n m赤nima inhibitoria es del 10 % para el producto activo. Con la materia prima obtenida se prepararon suspensiones para la candidiasis bucal con 0,6; 0,8 y 1,0 % de hidroxipropilmetil celulosa como agente suspensor. Seg迆n el estudio de estabilidad f赤sica, la formulaci車n B con 0,8 % de hidroxipropilmetil celulosa presenta los mejores resultados hasta los 60 d de estudio. A methodology was developed to decolorize a natural zeolite modified by using orthophosporic acid 100 %. The product obtained was chemically controlled and no changes were observed in its structure as a result of decolorization, which was confirmed by determining its antimicrobial activity in vitro in the presence of grampositive and gramnegative microbial strains and of Candida albicans. It was proved that the minimum inhibitory concentration is 10 % for the active product. Suspensions were prepared with the raw material obtained for oral candidiasis with 0.6; 0.8 and 1.0 % of hydroxypropylmethyl cellulose as a suspension agent. According to the physical stability study, formulation B with 0.8 % of hydroxypropylmethyl cellulose presents the best results until the 60 days of study.
%K CEOLITAS
%K EVALUACION DE MEDICAMENTOS
%K ZEOLITES
%K DRUG EVALUATION
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75151999000300006