%0 Journal Article
%T Evaluaci車n costo-efectividad de lidoca赤na al 5 % y bupivaca赤na al 0,5 % en anestesia espinal Cost-effectiveness evaluation of 5% lidocaine and 0,5% bupivacaine in spinal anesthesia
%A Er谷ndira Gonz芍lez Orozco
%A Rogelio A Fern芍ndez Arg邦elles
%A Antonio Dur芍n Ortega
%A Mar赤a Cristina Lara Bastanzuri
%J Revista Cubana de Farmacia
%D 2006
%I ECIMED
%X Se realiz車 un estudio econ車mico prospectivo de costo-efectividad con datos primarios de efectividad obtenidos de un ensayo cl赤nico aleatorizado, donde se comparan 2 anest谷sicos v赤a espinal: lidoca赤na al 5 % y bupivaca赤na al 0,5 %. La efectividad se evalu車 como la probabilidad de aparici車n de s赤ntomas neurol車gicos transitorios, reacci車n adversa propia de este grupo de medicamentos. Se formaron aleatoriamente 2 grupos de pacientes que requer赤an cirug赤as por debajo del ombligo con una duraci車n no mayor de 120 min, con la aplicaci車n de cada una de las opciones de anestesia estudiada a cada grupo, 109 pacientes en el grupo de lidoca赤na y 97 en el grupo de bupivaca赤na. Un especialista en Neurolog赤a evalu車 a ciegas la condici車n neurol車gica posquir迆rgica de cada paciente antes y 24 h despu谷s de la intervenci車n. Se calcularon los costos de cada alternativa, que incluyeron los ocasionados por la toxicidad neurol車gica, y se determinaron las relaciones costo-efectividad y los costos incrementales. El grupo de bupivaca赤na result車 la alternativa con mejor relaci車n costo-efectividad A prospective economic study of cost-effectiveness with primary effectiveness data from a randomized clinical assay was carried out, in which two spinal anesthetic substances were compared: 5% lidocaine and 0,5% bupivacaine. The effectiveness was evaluated in terms of the probabilities of occurrence of transient neurological symptoms, which are an adverse reaction inherent to this group of drugs. Two groups of patients were randomly assigned, who required a less than 120 min. surgery under the navel, with the application of each studied anesthetic options to each group. One hundred and nine patients were administered lidocaine and 97 were applied bupivacaine. An expert in Neurology blindly evaluated the neurological condition of each patient before and 24 hours after the surgery. The costs of each option were estimated including those due to neurological toxicity. Cost-effectiveness ratio and incremental costs were also determined. Bupivacaine turned to be the option with a better cost-effectiveness ratio
%K Anest谷sicos locales
%K costo-efectividad
%K s赤ndrome neurol車gico transitorio
%K Local anesthetic drugs
%K cost-effectiveness
%K transient neurological syndrome
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152006000100008