%0 Journal Article
%T Validaci車n del ensayo de disoluci車n de las tabletas de propiltiuracilo 50 mg Validation of the dissolution assay of propylthiouracil 50 mg
%A Caridad M Garc赤a Peˋa
%A Jacqueline Aylema Romero Diaz
%A Mar赤a Olga Vald谷s Bendoyro
%A Juan Lugones Fern芍ndez
%J Revista Cubana de Farmacia
%D 2008
%I ECIMED
%X Se valid車 un m谷todo para evaluar la disoluci車n de las tabletas de propiltiuracilo 50 mg por espectrofotometr赤a, con detecci車n ultravioleta a 274 nm. Se evaluaron los par芍metros de especificidad, linealidad, precisi車n e influencia de la filtraci車n. La curva de linealidad se realiz車 en el rango de 3,32 a 7,75 米g/mL con un coeficiente de correlaci車n igual a 0,99984; la prueba estad赤stica para el intercepto y la pendiente se consider車 no significativa. En el estudio de la influencia de la filtraci車n se demostr車 que en la filtraci車n no se adsorbe el principio activo ni se aportan interferencias al filtrado, por lo que es posible su empleo A method to evaluate the dissolution of propylthiouracil tablets 50 mg by spectrophotometry, with ultraviolet detection of 274 nm, was validated. Specificity, linearity, precision and filtration influence were the evaluated parameters. The linearity curve was made at the range from 3.32 to 7.75 米g/mL with a correlation coefficient equal to 0.99984. The statistical test for the interval and the slope was not significant. In the study of filtration influence it was proved that the active principle was not absorbed in the filtration and that there were no interferences in the filtration, which made its use possible
%K Propiltiuracilo
%K validaci車n
%K ensayo de disoluci車n
%K Propylthiouracil validation
%K dissolution assay
%U http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0034-75152008000100005