%0 Journal Article
%T Interlinkages in the Tunica Media of Goat Aorta Interrelaciones en la T迆nica Media de la aorta de Cabra
%A Julius Ogeng'o
%A Adel Abdel Malek
%A Stephen Kiama
%J International Journal of Morphology
%D 2010
%I Sociedad Chilena de Anatom赤a
%X The arrangement and interconnections between various components of the aortic wall influence its physicomechanical properties and functional alterations that occur in disease and ageing. The goat is a suitable model for studying cardiovascular disease, but details of the intrinsic organization of its aorta are unknown. This study therefore investigated the histomorphology of aortic tunica media in the goat by transmission electron microscopy. Sixteen healthy juvenile and adult domestic male goats (capra hircus) purchased from livestock farms in the outskirts of Nairobi were used in the study. The animals were euthanized with overdose of sodium pentabarbitone 20mg/kg, and fixed with 3% phosphate buffered glutaraldehyde solution by gravimetric perfusion. Specimens obtained from the thoracic aorta (T9) were post fixed in osmium tetroxide, and prepared for durcupan embedding. Ultrathin sections stained with uranyl acetate/lead citrate were examined by EM 201 Phillips   electron microscope. Elastic and collagen fibres were structurally interconnected. Elastic lamellae, collagen and elastic fibres were linked to smooth muscle cells through areas of high electron density while smooth muscle cells were interconnected various inter cellular connections. The physical interlinkages between the components of the tunica media confer plasticity, adaptability and flexibility to the aortic wall enabling it to function as a mechanically homogenous structure. Disruptions of this structure in atherosclerosis and aging may disturb the vascular integrity and predispose to aneurysm formation. Los relaciones e interconexiones entre los distintos componentes de la pared a車rtica influyen en sus propiedades fisicomec芍nicas y en las alteraciones funcionales que se producen en la enfermedad y el envejecimiento. La cabra es un modelo adecuado para el estudio de las enfermedades cardiovasculares, pero los detalles de la organizaci車n propia de la aorta son desconocidos. Por tanto, se investig車 la histomorfolog赤a de la t迆nica media a車rtica en la cabra mediante microscop赤a electr車nica de transmisi車n. Fueron utilizadas 16 cabras (Capra hircus) dom谷sticas macho, j車venes y adultas sanas, adquiridas en las explotaciones ganaderas en las afueras de Nairobi fueron utilizadas. Los animales fueron sacrificados con una sobredosis de 20 mg/kg de pentobarbital s車dico, y se fijaron con una soluci車n de fosfato de glutaraldeh赤do al 3% por perfusi車n gravim谷trica. Las muestras obtenidas de la aorta tor芍cica (T9) fueron puestas en tetr車xido de osmio, y se prepararon para inclusi車n en durcupan. Seccione
%K Matriz
%K M迆sculo liso
%K Interrelaci車n
%K Aorta
%K Cabra
%K Matrix
%K Smooth muscle
%K Interlinkage
%K Aorta
%K Goat
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000200013