%0 Journal Article
%T Effects of Sucralose Ingestion on Fetal and Placental Weights and Umbilical-Cord Length: Experimental Study Efectos de la Ingesti車n de Sucralosa sobre el Peso Fetal y Placentario y la Longitud del Cord車n Umbilical: Estudio Experimental
%A Ademir B Rodero
%A Fernando Batig芍lia
%A Reinaldo Azoubel
%A Arianne Assis Moura
%J International Journal of Morphology
%D 2010
%I Sociedad Chilena de Anatom赤a
%X Sucralose is a sweetener of general use in over three thousand products (beverages, foods and medical diets), with utilization currently permitted for the general population in more than 80 countries, including for women of reproductive age. There is little information on the safe use of sucralose, and experimental studies have suggested that the administration of some sweeteners, by diverse routes, retards not only fetal and placental development but also umbilical cord size. The present study aimed to estimate the fetal and placental weights and umbilical-cord length in fetuses from rat dams, after ingestion and non-ingestion of sucralose. In the treated group (5 dams), sucralose was administered (via gavage) at the dose of 30 mg/kg/day, from the 10th to 14th day of pregnancy. In the control group (5 dams), saline solution was administered, at the same dose and by the same route. On the 20th gestation day, both groups were sacrificed for weighing of the fetuses and placentas and measurement of umbilical-cord length. Mean values of fetal weight and umbilical-cord length of the treated group were significantly lower than controls (Mann-Whitney Test, p<0.001). Placental weight did not differ statistically between treated and control groups. It can be concluded from the present work that sucralose ingestion at 30 mg/kg/day, from days 10 to 14 of pregnancy, diminished fetal weight and umbilical-cord length, which suggests passage of sucralose through the placental membrane. La sucralosa es un edulcorante de uso general en m芍s de tres mil productos (bebidas, alimentos y dietas m谷dicas), con permisos de utilizaci車n para la poblaci車n general en m芍s de 80 pa赤ses, entre ellos mujeres en edad reproductiva. Hay poca informaci車n sobre el uso seguro de la sucralosa, y los estudios experimentales han sugerido que la administraci車n de algunos edulcorantes, por diversas v赤as, no s車lo retrasa el desarrollo del feto y la placenta, sino tambi谷n el tama o del cord車n umbilical. Este estudio tuvo como objetivo estimar el peso fetal y placentario y la longitud del cord車n umbilical de los fetos de ratas madres despu谷s de la ingesti車n y la no ingesti車n de sucralosa. En el grupo tratado (5 cr赤as), la sucralosa se administr車 (a trav谷s de sonda) en una dosis de 30 mg/kg/d赤a, desde el d赤a 10 hasta 14 de la pre ez. En el grupo control (5 cr赤as), se administr車 soluci車n salina, con la misma dosis y por la misma v赤a. En el d赤a 20 de la gestaci車n, ambos grupos fueron sacrificados, para determinar el peso de los fetos y de las placentas y la medici車n de la longitud del cord車n umbilical.
%K Sucralosa
%K Feto
%K Placenta
%K Cord車n umbilical
%K Peso
%K Sucralose
%K Fetus
%K Placenta
%K Umbilical cord
%K Weight
%U http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022010000300025