%0 Journal Article
%T S¨ªndrome de anticuerpos antifosfol¨ªpidos asociado a la presencia de inhibidor adquirido del factor IX en una paciente sin hemofilia Antiphospholipid antibody syndrome associated with acquired factor IX inhibitor in a non-hemophilic patient
%A Philippe Chalem
%J Acta Medica Colombiana
%D 2011
%I Asociacion Colombiana de Medicina Interna
%X Se presenta el caso de una paciente de 23 a os de edad, con diagn¨®stico de s¨ªndrome de anticuerpos antifosfol¨ªpidos, con un cuadro t¨ªpico de trombosis venosa profunda recurrente y p¨¦rdidas fetales, en presencia de anticoagulante l¨²pico y anticuerpos anticardiolipina positivos. En el transcurso de su enfermedad presenta manifestaciones hemorr¨¢gicas, no explicadas por el uso de anticoagulantes orales. Los estudios de hematolog¨ªa permitieron documentar una disminuci¨®n de los factores IX y VIII, con evidencia de inhibidor espec¨ªfico del factor IX. La deficiencia de factores de la coagulaci¨®n mejor¨® gracias al uso de esteroides y ciclofosfamida. (Acta Med Colomb 2011; 36: 196-199) We report the case of a 23-year-old female patient with an antiphospholipid syndrome characterized by recurrent deep venous thromboses and fetal losses, with positive lupus anticoagulant and anticardiolipin antibodies. During the course of the disease she had hemorrhagic manifestations not attributable to oral anticoagulants. Hematological analyses documented reduced levels of factors IX and VIII, with evidence of a specific inhibitor of factor IX. The deficiency of clotting factors improved with steroids and cyclophosphamide. (Acta Med Colomb 2011; 36: 196-199)
%K s¨ªndrome de anticuerpos antifosfol¨ªpidos
%K hemorragia
%K anticoagulantes circulantes
%K factor IX
%K factor VIII
%K inhibidor adquirido del factor IX
%K antiphospholipid syndrome
%K hemorrhage
%K clotting factors inhibitors
%K factor IX
%K factor VIII
%K acquired factor IX inhibitor
%U http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0120-24482011000400006