%0 Journal Article
%T A NEW PROTOCOL FOR THE SYNTHESIS OF 2-AMINOTHIOPHENES THROUGH THE GEWALD REACTION IN SOLVENT-FREE CONDITIONS. Ein neues Protokoll f¨¹r den Synthese von 2-Aminothiophene DURCH DIE Gewald Reaktion in l sungsmittelfreien Bedingungen.
%A Josu¨¦ S.Bello Forero
%A Erika M. de Carvalho
%A Joel Jones Junior and Flavia M. da Silva
%J Heterocyclic Letters
%D 2011
%I Raman Publications
%X A new set of green conditions have been developed for the preparation of tetrasubstituted 2-aminothiophene derivatives through the Gewald reaction between the respective ketones, ethyl cyanoacetate and elemental sulfur in the presence of morpholine. The synthesis was carried out under solvent-free conditions by stirring components at room temperature.
%K 2-Aminothiophenes
%K Gewald reaction
%K Green chemistry
%K Solvent-free
%U http://heteroletters.org/issue1/9.html