%0 Journal Article
%T SYNTHESIS AND BIOLOGICAL EVALUATION OF NOVEL N-(SUBSTITUTED BENZYL)-N-PROPYL-2-(TRICHLOROMETHYL) QUINAZOLIN-4-AMINE DERIVATIVES AS CYTOTOXIC AGENTS Synthese und biologische Evaluierung neuartiger N-(SUBSTITUIERTEN BENZYL)-N-propyl-2-(trichlormethyl) chinazolin-4-amin DERIVATE ALS zytotoxischen Wirkstoffen
%A Maneesh Kumar Srivastav
%A N. Srinivasulu
%A S. M. Shantakumar
%J Heterocyclic Letters
%D 2013
%I Raman Publications
%X A series of novel 2-trichloromethyl quinazoline derivatives bearing tertiary amine group at the 4th position were synthesized and evaluated for their in-vitro cytotoxicity against human lung carcinoma cell line A549 and Human colorectal adernocarcinoma cell line HT-29 by MTT assay method. All the molecules were designed on the basis of Hydrogen bond acceptor, trichloro methyl group and presence of aromatic ring. The targeted compounds (8a-o) were synthesized from 4-chloro-2-(trichloromethyl) quinazolines and N-(substituted benzyl) propan-1-amines in alcoholic medium under reflux for 15-18 h. Compounds 8f and 8l exhibited highest cytotoxicity against human lung carcinoma A549 cell line (IC50 7.5 and 6.8  G) and human colon carcinoma HT-29 cell line (IC50 8.2 and 8.0  G) among the derivatives
%K Cytotoxicity
%K 2-trichlomethyl quinazoline
%K MTT assay
%K A549 cell lines
%K HT-29 cell lines
%U http://heteroletters.org/issue31/1.html