%0 Journal Article
%T Immunohistochemical detection of laminin-1 and Ki-67 in radicular cysts and keratocystic odontogenic tumors
%A Mohamed S Ayoub
%A Houry M Baghdadi
%A Moataz El-Kholy
%J BMC Clinical Pathology
%D 2011
%I BioMed Central
%R 10.1186/1472-6890-11-4
%X Thirteen cases of RCs and twelve cases of KCOTs were included in this study. Antibodies against laminin-1 and Ki-67 were used as primary antibodies.ten cases out of thirteen cases of RCs were immunopositive to laminin-1. The immunonegative cases of RCs showed high degree of inflammation inside the connective tissue wall. One case out of twelve cases of KCOTs was immunopositive to laminin-1 and the rest were immunonegative. Seven cases out of thirteen cases of RCs showed immunopositivity for Ki-67 with increased numbers of immunopositive cells when the inflammation was severe in the connective tissue wall. All KCOTS were immunopositive to Ki-67.The benign nature of radicular cysts and the aggressive behavior of keratocystic odontogenic tumors could be explained by the expression of laminin and Ki-67. Laminin-1 and Ki-67 could be valuable markers for the prediction of the biologic behavior of cystic lesions.Radicular cysts are a direct sequel to chronic apical periodontitis following the death of dental pulp [1]. The epithelial rests of Malassez in periapical granuloma may be stimulated to proliferate by inflammatory stimuli [2]. The morphological aspects of the epithelium have been considered to reflect the functional activity of the RCs [3]. RCs depict a thin, regular and atrophic layer of stratified squamous epithelium, usually with mild to moderate inflammatory reaction [4]. The underlying supportive connective tissue might be focally or diffusely infiltrated with mixed inflammatory cells population [5].Keratocystic odontogenic tumor (KCOT), previously known as odontogenic keratocyst (OKC), is a relatively common developmental odontogenic cyst that arises from the dental lamina remnants [6]. An important aspect of the OKC that should be underlined is that it can represent one component of the nevoid basal cell carcinoma syndrome (NBCS) [7]. Several studies have shown that the OKC is well recognized by its invasive potential [8], thus it tends to grow within the me
%U http://www.biomedcentral.com/1472-6890/11/4