%0 Journal Article
%T Estimate of toxically influence of silicon carbide nanoparticles according histopatologycal changes
%A Ristoski Trpe
%A Vasilevska Violeta
%A Mladenovska Kristina
%A Grozdanov Anita
%J Macedonian Veterinary Review
%D 2013
%I Ss.Cyril and Methodius University, Skopje
%X Taking in consideration a very wide application of nanoparticules in different industrial sectors due to their remarkable properties for implementation in different products, very important part for future development of nanotechology is following a histopatologycal changes provoke of this material.Silicon carbide (SiC) as ceramic material with high thermal conductivity, high stability, good wear resistance and small thermal expansion coefficient is very applied in ceramic¡¯s industry, power electronics, biomaterials, pharmaceutics etc. Histopathological changes of SiC particles were investigate on 4 weeks old female Wistar rats divided into four groups (two control and two experimental groups), sacrificed 2, 7 and 14 days after treatment. Histopathological diagnosis was performed on heart, liver, spleen, kidneys, lung, brain, gastrointestinal tract, using standard Hematoxilin-eosin staining methods. The main toxicological influences of SiC were observed on liver, lungs and gastrointestinal tract.
%K nanoparticules
%K SiC
%K toxicity
%K histopathology
%U http://www.macvetrev.mk/2013-1/Mac%20Vet%20Rev%202013;%2036%20%281%29;%2025-31.pdf