%0 Journal Article
%T Antibacterial mono- and sesquiterpene esters of benzoic acids from Iranian propolis
%A Boryana Trusheva
%A Ivelin Todorov
%A Mariana Ninova
%A Hristo Najdenski
%A Ali Daneshmand
%A Vassya Bankova
%J Chemistry Central Journal
%D 2010
%I BioMed Central
%R 10.1186/1752-153x-4-8
%X From Iranian propolis from the Isfahan province, five individual components were isolated: the prenylated coumarin suberosin 1, and four terpene esters: tschimgin (bornyl p-hydroxybenzoate) 2, tschimganin (bornyl vanillate) 3, ferutinin (ferutinol p-hydroxybenzoate) 4, and tefernin (ferutinol vanillate) 5. All of them were found for the first time in propolis. Compounds 2 - 5 demonstrated activity against Staphylococcus aureus.The results of the present study are consistent with the idea that propolis from unexplored regions is a promising source of biologically active compounds.Propolis (bee glue) has been used as a remedy since ancient times. At present, propolis is a popular remedy in the folk medicine of many nations and a row material for numerous over-the-counter preparations, health foods and beverages. Propolis has been proved to possess valuable biological activities: antimicrobial, antiviral, anti inflammatory, antioxidant, antitumor, etc. [1,2]. Bee glue is a plant derived product: bees collect it from resinous plant parts, and its chemical composition strongly varies in different eco-geographic zones. Despite the chemical variability however, it always demonstrates considerable biological activity, especially antimicrobial activity [3,4]. For this reason, propolis from unexplored regions attracts the attention of scientists in the search for new bioactive molecules [5]. In this article we report on the isolation of antibacterial terpene esters of phenolic acids, new propolis constituents, from bee glue originated from the central part of Iran.The total ethanol extract of Iranian propolis and the light petroleum fraction of this extract demonstrated significant antibacterial activity against Staphylococcus aureus, similar to the activity of the poplar type propolis. For this reason, GC-MS chemical profiling of this propolis was performed.The GC-MS analysis of the ethanol extract after silylation (data not shown) revealed the presence of the poplar bud met
%U http://journal.chemistrycentral.com/content/4/1/8