%0 Journal Article
%T A case of acute promyelocytic leukemia with morphologic multilineage dysplastic changes
%A Setsuki Isono
%A Katsuyasu Saigo
%A Keiko Nagata
%A Keiko Numata
%J Hematology Reports
%D 2013
%I PAGEPress Publications
%R 10.4081/hr.2013.e5
%X Although reports of typical acute promyelocytic leukemia (APL) cases rarely mention dysplastic changes, this report concerns a rare case of APL with tri-lineage dysplastic changes resembling the characteristic features of myelodysplastic syndrome (MDS). The patient, a 77-year-old Japanese male, was diagnosed as having pancytopenia with hematologic morphological abnormalities comprising micromegakaryocytes, neutrophils with hypo-granulation and negative peroxidase activity, and erythroblasts containing nuclei with abnormalities such as karyorrhexis. Although there is one report of a case of transformation of de novo MDS into APL and several reports of cases of therapy-related MDS transformed into APL, our patient had no history of cytopenia or of either chemo or radiation therapy. Our case can thus be considered to constitute a rare case of APL with dysplastic morphology.
%K acute promyelocytic leukemia
%K dysplasia
%K all-trans retinoic acid
%U http://www.pagepress.org/journals/index.php/hr/article/view/4511