%0 Journal Article
%T Thrombotic thrombocytopenic purpura in a patient with interferon treated hepatitis C successfully treated with Rituximab
%A Nishant Poddar
%A Jen C. Wang
%J Hematology Reports
%D 2013
%I PAGEPress Publications
%R 10.4081/hr.2013.e2
%X Thrombotic thrombocytopenic purpura (TTP) is a life threatening condition associated with formation of platelet thrombi. Deficiency of ADAM TS 13 with presence of inhibitory anti-ADAM TS 13 Immunoglobulin G antibody is seen in patients with acquired TTP. TTP in patients on interferon therapy for chronic hepatitis C has rarely been reported. Furthermore, successful treatment of an initial episode of acute refractory acquired TTP, in a patient of chronic hepatitis C during interferon therapy with Rituximab, has not been previously reported. Here we describe a case of acute refractory acquired TTP associated with pegylated interferon therapy for her chronic hepatitis C infection. Initially refractory to plasmapheresis and steroids, she was successfully treated with Rituximab and plasmaphersis without any evidence of reactivation of hepatitis.
%K thrombotic thrombocytopenic purpura
%K interferon
%K hepatitis C
%K Rituximab
%U http://www.pagepress.org/journals/index.php/hr/article/view/4420