%0 Journal Article
%T Hypoglycemic and antilipidemic properties of kombucha tea in alloxan-induced diabetic rats
%A Ahmed Aloulou
%A Khaled Hamden
%A Dhouha Elloumi
%A Madiha Bou Ali
%A Khaoula Hargafi
%A Bassem Jaouadi
%A Fatma Ayadi
%A Abdelfettah El Feki
%A Emna Ammar
%J BMC Complementary and Alternative Medicine
%D 2012
%I BioMed Central
%R 10.1186/1472-6882-12-63
%X Alloxan diabetic rats were orally supplied with kombucha and black tea at a dose of 5 mL/kg body weight per day for 30 days, fasted overnight, and sacrificed on the 31st day of the experiment. Their bloods were collected and submitted to various biochemical measurements, including blood glucose, cholesterol, triglcerides, urea, creatinine, transaminases, transpeptidase, lipase, and amylase activities. Their pancreases were isolated and processed to measure lipase and ¦Á-amylase activities and to perform histological analysis.The findings revealed that, compared to black tea, kombucha tea was a better inhibitor of ¦Á-amylase and lipase activities in the plasma and pancreas and a better suppressor of increased blood glucose levels. Interestingly, kombucha was noted to induce a marked delay in the absorption of LDL-cholesterol and triglycerides and a significant increase in HDL-cholesterol. Histological analyses also showed that it exerted an ameliorative action on the pancreases and efficiently protected the liver-kidney functions of diabetic rats, evidenced by significant decreases in aspartate transaminase, alanine transaminase, and gamma-glytamyl transpeptidase activities in the plasma, as well as in the creatinine and urea contents.The findings revealed that kombucha tea administration induced attractive curative effects on diabetic rats, particularly in terms of liver-kidney functions. Kombucha tea can, therefore, be considered as a potential strong candidate for future application as a functional supplement for the treatment and prevention of diabetes.
%U http://www.biomedcentral.com/1472-6882/12/63/abstract