%0 Journal Article
%T Role of the IRS-1 and/or -2 in the pathogenesis of insulin resistance in Dahl salt-sensitive (S) rats
%A Marlene F. Shehata
%J Heart International
%D 2009
%I Wichtig Editore, Milan
%R 10.4081/hi.2009.e6
%X Insulin resistance is a common finding in hypertensive humans and animal models. The Dahl salt-sensitive (S) rat is an ideal model of genetically predetermined insulin resistance and salt-sensitive hypertension. Along the insulin signaling pathway, the insulin receptor substrates 1 and 2 (IRS-1 and -2) are important mediators of insulin signaling. IRS-1 and/or IRS-2 genetic variant(s) and/or enhanced serine phosphorylation correlate with insulin resistance. The present commentary was designed to highlight the significance of IRS-1 and/or -2 in the pathogenesis of insulin resistance. An emphasis will be given to the putative role of IRS-1 and/or -2 genetic variant(s) and serine phosphorylation in precipitating insulin resistance.
%K Dahl S rats
%K insulin resistance
%K salt-sensitivity
%K insulin signaling pathway
%K genetic contributors
%K molecular contributors
%U http://www.pagepress.org/journals/index.php/hi/article/view/195