%0 Journal Article
%T Synthesis, antifungal and antibacterial activity for novel amide derivatives containing a triazole moiety
%A Ruping Tang
%A Linhong Jin
%A Chengli Mou
%A Juan Yin
%A Song Bai
%A Deyu Hu
%A Jian Wu
%A Song Yang
%A Baoan Song
%J Chemistry Central Journal
%D 2013
%I BioMed Central
%R 10.1186/1752-153x-7-30
%X A series of amide derivatives containing a triazole moiety were synthesized. All the obtained compounds were characterized through proton and carbon nuclear magnetic resonance spectroscopy, infrared spectroscopy, and elemental analysis. Preliminary antifungal activity test showed that some of the synthesized compounds exhibited moderate antifungal activity against P. sasakii, G. azeae, F. oxysporum, C. mandshurica, and P. infestans at 50 mg/L. Compound 4u displayed more potent antifungal activity against P. sasakii and G. azeae than hymexazol. Preliminary antibacterial activity results showed that some of the synthesized compounds exhibited high anti-bacterial activity against R. solanacearum at 200 mg/L. Compounds 4m and 4q displayed high antibacterial activity against R. solanacearum, with 71% and 65% inhibitory rates, respectively.A series of novel amide derivatives containing 1,2,4-triazole moiety were synthesized through the reaction of intermediate 3 with different acyl chlorides and anhydrous potassium carbonates in anhydrous tetrahydrofuran at 50?C, using 2,4-dichloroacetophenoneas as a starting material. The title compounds exhibited high inhibitory effects against P. sasakii, R. solanacearum, and G. azeae.
%U http://journal.chemistrycentral.com/content/7/1/30/abstract