%0 Journal Article
%T Quince a os del s¨ªndrome antifosfolip¨ªdico catastr¨®fico:  Qu¨¦ hemos aprendido? Fifteen years of the catastrophic antiphospholipid syndrome: What have we learned?
%A Jos¨¦ A G¨®mez Puerta
%J Revista Colombiana de Reumatolog¨ªa
%D 2007
%I Asociaci¨®n Colombiana de Reumatolog¨ªa
%X El s¨ªndrome antifosfolip¨ªdico (SAF) castastr¨®fico es una variante inusual pero potencialmente letal del SAF. El SAF catastr¨®fico fue descrito por primera vez hace ya 15 a os y se caracteriza por la presencia de fallo multiorg¨¢nico en un corto per¨ªodo de tiempo acompa ado de trombosis de peque os vasos. En un porcentaje considerable de pacientes los eventos tromb¨®ticos son desencadenados por un factor precipitante, tales como infecciones, cirug¨ªas, traumatismos o brotes "l¨²picos" entre otros. El tratamiento de elecci¨®n se basa en la combinaci¨®n de heparina y esteroides endovenosos, inmunoglobulinas endovenosas y/o recambios plasm¨¢ticos. La supervivencia del SAF catastr¨®fico ha mejorado durante los ¨²ltimos a os, aunque la mortalidad global de dichos pacientes sigue estando alrededor de un 50%. The catastrophic antiphospholipid syndrome (APS) was described 15 years ago as a potentially life threatening variant of presentation of APS. Catastrophic APS is characterized by clinical evi-dence of multiple organ involvement developed over a very short time period and histopathological evidence of multiple small vessel occlusions. An early recognition of potential triggers such as infections, surgery, traumatisms or lupus "flares" is mandatory in these patients. The combination of high doses of intravenous (iv) heparin, iv steroids, iv gammaglobulins and/or repeated plasma exchanges is the basic treatment of choice for all patients with this severe condition. The survival rate of catastrophic APS patients have improved during last years, however, global mortality is around 50%.
%K Anticuerpos antifosfolip¨ªdicos
%K s¨ªndrome antifosfolip¨ªdico catastr¨®fico
%K fallo multiorg¨¢nico
%K Antiphospholipid antibodies
%K catastro-phic antiphospholipid syndrome
%K Multiorganic failure
%U http://www.scielo.org.co/scielo.php?script=sci_arttext&pid=S0121-81232007000200005