%0 Journal Article
%T Study of serum malondialdehyde and whole blood reduced glutathione in emphysema patients
%A Nagaraj R.Shetkar
%A Anand Pyati
%A Rajesh CS
%J International Journal of Medical Research and Health Sciences
%D 2013
%I Sumathi Publications
%R 10.5958/j.2319-5886.2.2.032
%X Background: Emphysema is associated with high incidence of morbidity and mortality. The imbalance between oxidants and antioxidants is thought to play an important role in the pathogenesis of Emphysema. Methods: A total number of 80 subjects comprising of 40 healthy controls and 40 Emphysema cases were studied. In all the subjects, serum levels of malondialdehyde (MDA) as a biomarker of lipid peroxidation and antioxidant whole blood reduced glutathione (GSH) were estimated. Results: The level of whole blood reduced glutathione was significantly decreased in emphysema patients when compared to controls. Serum MDA was significantly increased in Emphysema patients when compared to controls. Conclusion: The presence of increased systemic oxidative stress in emphysema patients seems to be associated with current active smoking and systemic inflammation. The decrease in antioxidants levels appears to be mainly a consequence of increased oxidative stress. This suggests that oxidative stress is likely to be involved in pathogenesis of emphysema.
%K Oxidative stress
%K Antioxidants
%K Emphysema
%K Whole blood reduced glutathione
%K MDA.
%U http://ijmrhs.com/study-of-serum-malondialdehyde-and-whole-blood-reduced-glutathione-in-emphysema-patients/