%0 Journal Article
%T A NEW INCOME IN PEDIATRIC PATHOLOGY: GASTROENTEROİ\ PANCREATIC NEUROENDOCRINE TUMORS. II: CARCINOID TUMORS
%A Smaranda DIACONESCU
%A Marin Burlea
%A Claudia OLARU
%A Nicoleta GIMIGA
%J International Journal of Medical Dentistry
%D 2013
%I Academy of Romanian Scientists
%X Carcinoid tumors are classified according to their embryologic origin, that might be the foregut (stomach, duodenum, biliary tree and also lung, thymus, thyroid), the midgut (ileum, right colon) and the hindgut (left colon and rectum). The clinical picture of these lesions is variaİ\ ble, evidencing completely asymptomatic cases, symptoms due to complications (acute appendicitis, peritonitis, obstructions or hemorrhages) or sudden apparition of carİ\ cinoid syndromes. The diagnosis includes urinary 5 ¨C HIAA, chromogranine A dosage and Kiİ\67 expression, as well as localising studies, such as echoendoscopy, videoİ\ capsule and enteroscopy, CT, MRI, selective abdominal angiography, somatostatinİ\receptorİ\scintigraphy (Octreİ\ oscan, SRI). Coronal contrastİ\enhanced CT or MRI angioİ\ gram can evaluate the mesenteric vessels spread before surgery. Upper endoscopy or/and colonoscopy can be performed to detect foregut or hindgut lesions. The treatİ\ ment is based on surgery and other removal techniques, such as cryoablation and radiofrequency ablation, tradiİ\ tional drugs: streptozocin, 5İ\fluorouracyl, doxorubicin, cyclophos phamide, mitomicycin, metrotrexate together with somatostatin analogs; the future belongs to radionuİ\ clideİ\radiopeptide therapy.
%K carcinoid tumors
%K children
%K somatostatin ana logs
%U http://www.ijmd.ro/articole/305_5%20diaconescu.pdf