%0 Journal Article
%T Detection of coronary microembolization by Doppler ultrasound in patients with stable angina pectoris during percutaneous coronary interventions under an adjunctive antithrombotic therapy with abciximab: design and rationale of the High Intensity Transient Signals ReoPro (HITS-RP) study
%A Daniel Kretzschmar
%A Christian Jung
%A Sylvia Otto
%A Stephan Utschig
%A Michael Hartmann
%A Thomas Lehmann
%A Atilla Yilmaz
%A Tudor C P£¿rner
%A Hans R Figulla
%A Markus Ferrari
%J Cardiovascular Ultrasound
%D 2012
%I BioMed Central
%R 10.1186/1476-7120-10-21
%X In the presented study we will test if abciximab (ReoPro£¿) infusion reduces high intensity transient signals in patients with stable angina pectoris undergoing PCI in comparison to standard therapy alone.The High Intensity Transient Signals ReoPro£¿ (HITS-RP) study will enroll 60 patients. It is a prospective, single center, randomized, double-blinded, controlled trial. The study is designed to compare the efficacy of intravenous abciximab administration for reduction of microembolization during elective PCI. Patients will be randomized in a 1:1 fashion to abciximab or placebo infusion. The primary end point of the HITS-RP-Study is the number of HITS during PCI measured by intracoronary Doppler wire. Secondary endpoints are bleeding complications, elevation of cardiac biomarkers or ECG changes after percutaneous coronary interventions, changes in coronary flow velocity reserve, hs-CRP elevation, any major adverse cardio-vascular event during one month follow-up.The HITS-RP-Study addresses important questions regarding the efficacy of intravenous abciximab administration in reducing microembolization and periprocedural complications in stable angina pectoris patients undergoing PCI.The trial is registered under http://www.drks-neu.uniklinik-freiburg.de/drks_web/:DRKS00000603 webcite.Following percutaneous coronary intervention (PCI) an increase of cardiac marker enzymes is relatively often observed and associated with reduced coronary flow velocity reserve (CFVR) [1]. Serum concentration of cardiac troponin I (cTNI) was reported to be increased in 30¨C40% of cases [2]. The troponin rise is the result of myocardial necrosis during PCI induced by embolization of atherosclerotic and thrombotic debris during balloon or stent inflation [3]. Troponin elevation is associated with dismal prognosis in patients with unstable angina [4] and PCI [5]. Periprocedural coronary microembolization occurs in about 25% of all PCIs. The incidence ranges from 0 to 70%, depending on the meth
%U http://www.cardiovascularultrasound.com/content/10/1/21