%0 Journal Article
%T Comparison between integrated backscatter intravascular ultrasound and 64-slice multi-detector row computed tomography for tissue characterization and volumetric assessment of coronary plaques
%A Takahiko Yamaki
%A Masanori Kawasaki
%A Ik-Kyung Jang
%A Owen Raffel
%A Yoshiyuki Ishihara
%A Munenori Okubo
%A Tomoki Kubota
%A Arihiro Hattori
%A Kazuhiko Nishigaki
%A Genzou Takemura
%A Hisayoshi Fujiwara
%A Shinya Minatoguchi
%J Cardiovascular Ultrasound
%D 2012
%I BioMed Central
%R 10.1186/1476-7120-10-33
%X Coronary lesions (125 lesions in 125 patients) were visualized by both integrated backscatter intravascular ultrasound (IB-IVUS) and 64-slice MDCT at the same site. The IB values were used as a gold standard to determine the cut off values of HU for the discrimination of plaque components.Plaques were classified as lipid pool (n =50), fibrosis (n =65) or calcification (n =35) by IB-IVUS. The HU of lipid pool, fibrosis and calcification were 18£¿¡À£¿18 HU (£¿19 to 58 HU), 95£¿¡À£¿24 HU (46 to 154 HU) and 378£¿¡À£¿99 HU (188 to 605 HU), respectively. Using receiver operating characteristic curve analysis, a threshold of 50 HU was the optimal cutoff values to discriminate lipid pool from fibrosis. Lipid volume measured by MDCT was correlated with that measured by IB-IVUS (r =0.66, p <0.001), whereas fibrous volume was not (r =0.21, p =0.059).Lipid volume measured by MDCT was moderately correlated with that measured by IB-IVUS. MDCT may be useful for volumetric assessment of the lipid volume of coronary plaques, whereas the assessment of fibrosis volume was unstable.Enhanced multi-detector row computed tomography (MDCT) is a promising minimally-invasive method for detecting coronary artery disease. This method uses low radiation and requires the intravenous injection of contrast medium. The accuracy of MDCT for evaluating the degree of stenosis in coronary arteries was established in previous studies by direct comparison with angiography [1-6]. However, the ability of MDCT to characterize the tissue components of coronary plaques has been controversial, with some studies showing that MDCT produced results that were similar to conventional intravascular ultrasound (IVUS) [7,8], whereas other studies found that MDCT was not as accurate as IVUS [9,10]. Although MDCT has the potential for discriminating plaque components, the validity of this method in the clinical setting will depend upon development of objective and quantitative methods to analyze MDCT images.Recently, many techniq
%K Computed tomography
%K Integrated backscatter
%K Intravascular ultrasound
%K Coronary plaque
%U http://www.cardiovascularultrasound.com/content/10/1/33