%0 Journal Article %T Superantigens in Polyp Tissue of Patients with Chronic Rhino-Sinusitis, A Comparative Study: A Brief Report %A M Farhadi %A A Tabatabaee %A M Shekarabi %A S Noorbakhsh %J Tehran University Medical Journal %D 2012 %I Tehran University of Medical Sciences %X Background: Staphylococcus aureus secretes numerous superantigenes which trigger the inflammatory mechanisms of sinus mucosa and cause chronic rhino-sinusitis. This study was designed to evaluate the role of staphylococcus aureus superantigens in polyp tissues of patients with chronic rhino-sinusitis in comparison with a control group.Methods: Polyp tissue samples of 28 patients and mucosal specimens of 19 healthy individuals were evaluated for staphylococcus aureus bacterium superantigens, exotoxins A, B, C and D and TSST-1 with RT-PCR and ELISA methods Rasoul Akram Hospital during 2 years.Results: Polymerase chain reaction (PCR) results revealed that 88.2% of the patients and 45.5% of the controls had at least one type of superantigen (P=0.03). Evaluation of superantigens using ELISA method showed presence of at least one type of superantigen in the nasal samples of all patients and in 35.3% of the controls (P<0.001).Conclusion: A relationship between staphylococcal superantigens and nasal polyps is concluded from this study which indicates the probable role of these superantigens in the pathogenesis of nasal polyposis. %K ELISA %K RT-PCR %K Superantigens. %U http://journals.tums.ac.ir/upload_files/pdf/_/21865.pdf