%0 Journal Article
%T Association between human cartilage glycoprotein 39 (YKL-40) and arterial stiffness in essential hypertension
%A Wei-hong Ma
%A Xiu-ling Wang
%A Yi-meng Du
%A Yi-biao Wang
%A Yan Zhang
%A De-e Wei
%A Lin-lin Guo
%A Pei-li Bu
%J BMC Cardiovascular Disorders
%D 2012
%I BioMed Central
%R 10.1186/1471-2261-12-35
%X The relationship between serum levels of YKL-40 and arterial stiffness was evaluated in 93 essential hypertensive subjects and 80 normal subjects. Essential hypertensive subjects were divided into two groups based upon urinary albumin-to-creatinine ratio (ACR): nonmicroalbuminuric group, (ACR <30£¿mg/g, n£¿=£¿50) and microalbuminuric group (ACR ¡Ý30£¿mg/g, n£¿=£¿43). Large artery wall stiffness was assessed by measuring femoral arterial stiffness and carotid-femoral pulse wave velocity (cf-PWV). Serum levels of YKL-40 were determined by enzyme-linked immunosorbent assay (ELISA).The study demonstrated that YKL-40,cf-PWV and femoral arterial stiffness were increased significantly (P<0.05) in the hypertensive group compared with normal controls. These measurements were also increased significantly ( P<0.05) in the microalbuminuric group compared with the nonmicroalbuminuric group. YKL-40 was positively correlated with cf-PWV( r£¿=£¿0.44, P£¿=£¿0.000) and femoral arterial stiffness ( r£¿=£¿0.42, P =0.001). Multiple linear stepwise regression analysis showed that YKL-40 was the impact factor of arterial stiffness ( P<0.05).YKL-40 levels are elevated in essential hypertension subjects with an independent association between increasing YKL-40 levels and increasing arterial stiffness. The study suggests it played a positive role of YKL-40 in the progressing vascular complications in patients with essential hypertension.
%U http://www.biomedcentral.com/1471-2261/12/35/abstract