%0 Journal Article
%T A new survival model for hyperthermic intraperitoneal chemotherapy (HIPEC) in tumor-bearing rats in the treatment of peritoneal carcinomatosis
%A Joerg OW Pelz
%A Joerg Doerfer
%A Werner Hohenberger
%A Thomas Meyer
%J BMC Cancer
%D 2005
%I BioMed Central
%R 10.1186/1471-2407-5-56
%X A new peritoneal perfusion system in tumor bearing rats were tested. For this purpose CC531 colon carcinoma cells were implanted intraperitoneally in Wag/Rija rats. After 10 days of tumor growth the animals were randomized into three groups of six animals each: group 1: control (n = 6), group 2: HIPEC with mitomycin C in a concentration of 15 mg/m2 (n = 6), group III: mitomycin C i.p. as monotherapy in a concentration of 10 mg/m2 (n = 6). After 10 days, total tumor weight and the extent of tumor spread, as classified by the modified Peritoneal Cancer Index (PCI), were assessed by autopsy of the animals.No postoperative deaths were observed. Conjunctivitis, lethargy and loss of appetite were the main side effects in the HIPEC group. No severe locoregional or systemic toxity was observed. All control animals developed massive tumor growth. Tumor load was significantly reduced in the treatment group and was lowest in group II.The combination of hyperthermia with MMC resulted in an increased tumoricidal effect in the rat model. The presented model provides an opportunity to study the mechanism and effect of hyperthermic intraperitoneal chemotherapy and new drugs for this treatment modality.Peritoneal carcinomatosis (PC) represents an advanced form of cancer and is associated with a poor prognosis and quality of life. The peritoneal failure rate among patients who present with recurrence after colon cancer resection is approximately 25¨C35% [1]. The median survival time after manifestation of peritoneal carcinomatosis is about 6 months. If peritoneal carcinomatosis is present, normaly there is no curative treatment available for any of the tumors in the abdominal cavity.Hyperthermic intraperitoneal chemotherapy (HIPEC) is a new treatment modality. Complete cytoreductive surgery plus HIPEC is effective in the prevention and treatment of peritoneal metastases and it should lead to long-term survival for serosa-invasive carcinoma patients [2]. The efficacy of intraperitoneal
%U http://www.biomedcentral.com/1471-2407/5/56