%0 Journal Article
%T High fat diet-induced glucose intolerance impairs myocardial function, but not myocardial perfusion during hyperaemia: a pilot study
%A Charissa E van den Brom
%A Carolien S E Bulte
%A B Kloeze
%A Stephan A Loer
%A Christa Boer
%A R Bouwman
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-74
%X Male Wistar rats were randomly exposed to a high fat diet (HFD) or control diet (CD) (n£¿=£¿8 per group). After 4£¿weeks, rats underwent an oral glucose tolerance test. Subsequently, rats underwent (contrast) echocardiography to determine myocardial function and perfusion during baseline and dipyridamole-induced hyperaemia (20£¿mg/kg for 10£¿min).Four weeks of HFD feeding resulted in glucose intolerance compared to CD-feeding. Contractile function as represented by fractional shortening was not altered in HFD-fed rats compared to CD-fed rats under baseline conditions. However, dipyridamole increased fractional shortening in CD-fed rats, but not in HFD-fed rats. Basal myocardial perfusion, as measured by estimate of perfusion, was similar in CD- and HFD-fed rats, whereas dipyridamole increased estimate of perfusion in CD-fed rats, but not in HFD-fed rats. However, flow reserve was not different between CD- and HFD-fed rats.Diet-induced glucose intolerance is associated with impaired myocardial function during conditions of hyperaemia, but myocardial perfusion is maintained. These findings may result in new insights into the effect of glucose intolerance on myocardial function and perfusion during hyperaemia.Glucose intolerance defines the intermittent stage between transition from normal glucose levels to type 2 diabetes mellitus [1]. Glucose intolerance is a predictor of cardiovascular disease [2,3] and known to associate with vascular dysfunction and consequent impairment of organ perfusion as one of the appearing consequences [4]. Myocardial perfusion in combination with myocardial performance plays a central role in the balance between myocardial energy supply and demand. Under physiological conditions, myocardial blood flow and function are in balance [5], while pathophysiological conditions leading to vascular dysfunction, such as glucose intolerance, could alter balance between energy supply and demand. Although glucose intolerance-induced vascular dysfunction may
%K Glucose intolerance
%K Diet
%K Myocardial perfusion and function
%K Contrast echocardiography
%K Hyperaemia
%U http://www.cardiab.com/content/11/1/74