%0 Journal Article
%T Development of coronary heart disease and ischemic stroke in relation to fasting and 2-hour plasma glucose levels in the normal range
%A Feng Ning
%A Lei Zhang
%A Jacqueline M Dekker
%A Altan Onat
%A Coen DA Stehouwer
%A John S Yudkin
%A Tiina Laatikainen
%A Jaakko Tuomilehto
%A Kalevi Py£¿r£¿l£¿
%A Qing Qiao
%A DECODE Finnish and Swedish Study Investigators
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-76
%X Data from 9 Finnish and Swedish cohorts comprising 3743 men and 3916 women aged 25 to 90£¿years who had FPG£¿<£¿6.1£¿mmol/l and 2hPG£¿<£¿7.8£¿mmol/l and free of CVD at enrolment were analyzed. Hazard ratios (HRs) for first CHD and IS events were estimated for the individuals with 2hPG£¿>£¿FPG (Group II) compared with those having 2hPG ¡Ü FPG (Group I).A total of 466 (115) CHD and 235 (106) IS events occurred in men (women) during a median follow-up of 16.4£¿years. Individuals in Group II were older and had greater body mass index, blood pressure, 2hPG and fasting insulin than those in Group I in both sexes. Multivariate adjusted HRs (95% confidence intervals) for incidence of CHD, IS, and composite CVD events (CHD£¿+£¿IS) in men were 1.13 (0.93-1.37), 1.40 (1.06-1.85) and 1.20 (1.01-1.42) in the Group II as compared with those in the Group I. The corresponding HRs in women were 1.33 (0.83-2.13), 0.94 (0.59-1.51) and 1.11 (0.79-1.54), respectively.Within normoglycemic range individuals whose 2hPG did not return to their FPG levels during an OGTT had increased risk of CHD and IS.The role of hyperglycemia on the mortality from coronary heart disease (CHD) [1,2], stroke [3,4] and other cardiovascular diseases (CVDs) [5-7] has been well investigated. Two-hour plasma glucose (2hPG) is a better predictor than fasting plasma glucose (FPG) for incidence of CHD [8,9] and ischemic stroke (IS) [10] among individuals with hyperglycemia, but little is known about their impact within normoglycemic range. Previous studies have shown that insulin resistance and declined beta cell function are already presented in subjects with elevated normal FPG and/or 2hPG [11-13]. The upper normal level of the FPG [14,15] or 2hPG [16] has been found to increase the risk of type 2 diabetes. Our previous finding based on the DECODE (Diabetes Epidemiology: Collaborative analysis Of Diagnostic criteria in Europe) study demonstrated that individuals with normoglycemia, whose 2hPG did not return to the FPG levels d
%K Normoglycemia
%K Coronary heart disease
%K Ischemic stroke
%K Incidence
%U http://www.cardiab.com/content/11/1/76