%0 Journal Article
%T B-lymphocyte reconstitution after repeated rituximab treatment in a child with steroid-dependent autoimmune hemolytic anemia
%A Annelieke A.A. van der Linde
%A Ellen J.H. Schatorj¨¦
%A Annemieke M. van der Weij
%A Eugenie F.A. Gemen
%J Pediatric Reports
%D 2011
%I PAGEPress Publications
%R 10.4081/pr.2011.e28
%X We report the detailed long-term reconstitution of B-lymphocyte subpopulations, immunoglobulins, and specific antibody production after two courses of rituximab in a young, previously healthy girl with steroid-dependent autoimmune hemolytic anemia. B-lymphocyte subpopulations were surprisingly normal directly after reconstitution. However, there was a slower reconstitution after the second rituximab course, especially of non-switched and switched memory B-lymphocytes, and a temporary decline in IgM below age-matched reference values.
%K Autoimmune hemolytic anemia
%K Rituximab
%K Child
%K Immune reconstitution
%K B-lymphocytes
%U http://www.pagepress.org/journals/index.php/pr/article/view/2544