%0 Journal Article
%T Acute and chronic animal models for the evaluation of anti-diabetic agents
%A Suresh Kumar
%A Rajeshwar Singh
%A Neeru Vasudeva
%A Sunil Sharma
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-9
%X WHO reports Diabetes mellitus as one of the most common public health problems which will affect a total population of 220 million worldwide in the year 2020 [1,2]. The increasing prevalence of diabetes mellitus worldwide is a major societal issue because diabetes is a complex and multifactorial origin disease.The prevalence of diabetes is rising all over the world due to population growth, aging, urbanization and an increase of obesity and physical inactivity. Unlike in the West, where older persons are most affected, diabetes in Asian countries is disproportionately high in young to middle-aged adults. This could have long-lasting adverse effects on a nation's health and economy, especially for developing countries. The International Diabetes Federation (IDF) estimates the total number of people in India with diabetes to be around 50.8 million in 2010, rising to 87.0 million by 2030.According to recent estimates, approximately 285 million people worldwide (6.6%) in the 20-79 year age group will have diabetes in 2010 and by 2030, 438 million people (7.8%) of the adult population, is expected to have diabetes [3]. The largest increases will take place in the regions dominated by developing economies. According to the World Health Organization (WHO) criteria, the prevalence of known diabetes was 5.6% and 2.7% among urban and rural areas, respectively [4].Diabetes mellitus, often simply referred to as diabetes--is a group of metabolic diseases in which a person has high blood sugar, either because the body does not produce enough insulin, or because cells do not respond to the insulin that is produced. This high blood sugar produces the classical symptoms of polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). Diabetes mellitus can be of different types based on the cause of the disease.There are three main types of diabetes which are briefly described as below:It results from the body's failure to produce insulin, and presen
%K Streptozotocin
%K alloxan
%K diabetic rats
%K animal models
%K diabetes
%U http://www.cardiab.com/content/11/1/9