%0 Journal Article
%T Lipocalin-2, glucose metabolism and chronic low-grade systemic inflammation in Chinese people
%A Ying Huang
%A Zhen Yang
%A Zi Ye
%A Qin Li
%A Jie Wen
%A Xiaoming Tao
%A Lili Chen
%A Min He
%A Xuanchun Wang
%A Bin Lu
%A Zhaoyun Zhang
%A Weiwei Zhang
%A Shen Qu
%A Renming Hu
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-11
%X We evaluated serum lipocalin-2 in a cross-sectional sample of 2519 Chinese aged from 50 to 82 year in a Shanghai downtown district by ELISA. Glucose, insulin, lipid profile, inflammatory markers, and adipokines were also measured.Serum lipocalin-2 was significantly higher in subjects with isolated impaired fasting glucose, isolated impaired glucose tolerance, combined impaired fasting glucose/impaired glucose tolerance and newly-diagnosed type 2 diabetes than in those with normal glucose regulation. Lipocalin-2 elevation was clearly associated with a higher risk for impaired glucose regulation (OR 1.30 for each 10 ng/ml increase in serum lipocalin-2, 95% CI 1.23-1.62, p = 0.009) after adjustment of age, gender, smoking, alcohol drinking, family history of diabetes, serum CRP, serum adiponectin, serum CXCL5, HOMA-IR, BMI, and waist/hip ratio. The OR for participants with impaired glucose regulation and type 2 diabetes was 1.31 (95% CI 1.21-1.69, p < 0.001).Our findings suggest that elevated serum lipocalin-2 is closely and independently associated with impaired glucose regulation and type 2 diabetes.Obesity is a major risk factor for insulin resistance. It is well known that adipocytes could secrete a variety of biologically adipokines, which are thought to contribute to the development of insulin resistance and cardiovascular disease [1-3]. Lipocalin-2, a recently identified adipokine with high levels of expression and secretion in the white adipose tissue, seems to affect glucose metabolism and insulin sensitivity.Lipocalin-2, also known as neutrophil gelatinase-associated lipocalin, neu-related lipocalin, siderocalin, uterocalin, and 24p3, belongs to the lipocalin super family. It shows high affinity to several small hydrophobic ligands such as retinoids, fatty acids, pheromones, steroids and iron [4-6]. Lipocalin-2 was found expressed in kidney, brain, lung, liver, neutrophils, adipocytes as well as macrophages and was involved in varieties of biological function
%K Lipocalin-2
%K Impaired glucose regulation
%K Type 2 diabetes
%K Insulin resistance
%U http://www.cardiab.com/content/11/1/11