%0 Journal Article
%T Glycated hemoglobin and associated risk factors in older adults
%A Raul A Martins
%A John G Jones
%A Sean P Cumming
%A Manuel J Coelho e Silva
%A Ana M Teixeira
%A Manuel T Ver¨ªssimo
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-13
%X Data were available from 118 participants aged 65-95 years, including 72 women and 46 men. Anthropometric variables were taken, as was functional fitness, blood pressure and heart rate. Blood samples were collected after 12 h fasting, and HbA1c, hs-CRP, TG, TC, HDL-C, LDL-C, and glycaemia were calculated. Bivariate and partial correlations were performed to explore associations amongst the variables of interest. Differences between groups were explored by performing factorial analysis of variance.HbA1c levels ranged from 4.6%-9.4% with 93% of the cases below 6.5%. Women had higher HbA1c, glycaemia, TC, BMI, and lower and upper flexibility than men. Men had higher BW, WC, 6-min walking distance, and VO2peak than women. Age, SBP, DBP, HRrest, HRpeak, HDL-C, LDL-C, TG, TG/HDL-C ratio, Log10 hs-CRP, upper and lower strength, and agility and dynamic balance were similar in men and women. HbA1c had positive associations with glycaemia, HDL-C, TG/HDL-C, BW, WC, BMI, but not with functional fitness, TC, LDL-C, Log10 hs-CRP, PAD, or PAS. Obese participants had higher HbA1c than non-obese only when IDF and not USDHHS criteria were applied.Older women had higher HbA1c than men, even after controlling for BMI. HbA1c associates equally with BW, BMI or WC. Population-based criteria are recommended to classify obesity and to identify higher levels of HbA1c in obese older adults. HbA1c associates with atherogenic dyslipidemia particularly with TG and TG/HDL-C ratio, but not with TC, HDL-C, or LDL-C. HbA1c is not associated with hs-CRP, and with functional fitness and aerobic endurance.Fasting plasma glucose (FPG) and the oral glucose tolerance test (OGTT) are considered to be appropriate tests for diagnosing pre-diabetes and/or diabetes while OGTT is also considered an appropriate test for assessing diabetes risk in patients with impaired fasting glucose (IFG) [1]. As an alternative to these methods, an International Expert Committee, including representatives of the American Diabe
%K Glycated hemoglobin
%K Older adults
%K Risk factors
%K Functional fitness
%U http://www.cardiab.com/content/11/1/13