%0 Journal Article
%T High-sensitivity C-reactive protein to detect metabolic syndrome in a centrally obese population: a cross-sectional analysis
%A Corine den Engelsen
%A Paula S Koekkoek
%A Kees J Gorter
%A Maureen van den Donk
%A Philippe L Salom¨¦
%A Guy E Rutten
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-25
%X 1165 people with central obesity but without any previous diagnosis of hypertension, dyslipidemia, diabetes or cardiovascular disease, aged 20-70 years, underwent a physical examination and laboratory assays to determine the presence of the metabolic syndrome (NCEP ATP III criteria). Multivariable linear regression analyses were performed to assess which metabolic syndrome components were independently associated with hs-CRP. A ROC curve was drawn and the area under the curve was calculated to evaluate whether hs-CRP was capable to predict the presence of the metabolic syndrome.Median hs-CRP levels were significantly higher in individuals with central obesity with the metabolic syndrome (n = 417; 35.8%) compared to individuals with central obesity without the metabolic syndrome (2.2 mg/L (IQR 1.2-4.0) versus 1.7 mg/L (IQR 1.0-3.4); p < 0.001). Median hs-CRP levels increased with an increasing number of metabolic syndrome components present. In multivariable linear regression analyses, waist circumference and triglycerides were the only components that were independently associated with hs-CRP after adjusting for smoking, gender, alcohol consumption and the other metabolic syndrome components. The area under the ROC curve was 0.57 (95%-CI 0.53-0.60).Hs-CRP has limited capacity to predict the presence of the metabolic syndrome in a population with central obesity.The metabolic syndrome (MetS) is a cluster of cardiovascular risk factors associated with an increased risk for developing cardiovascular disease and type 2 diabetes [1]. In recent years systemic inflammation - which can be measured by high sensitivity C-reactive protein (hs-CRP) - has become an important marker for cardiovascular disease and type 2 diabetes [2-4]. Moreover hs-CRP is associated with the MetS and its separate components. Early diagnosis of the MetS is desirable as lifestyle interventions and adequate treatment of risk factors associated with the MetS can prevent cardiovascular disease [5,6]. H
%K Abdominal obesity
%K Metabolic syndrome
%K Screening
%K High-sensitivity C-reactive protein
%U http://www.cardiab.com/content/11/1/25