%0 Journal Article
%T LetĄ¯s prevent diabetes: study protocol for a cluster randomised controlled trial of an educational intervention in a multi-ethnic UK population with screen detected impaired glucose regulation
%A Laura J Gray
%A Kamlesh Khunti
%A Sian Williams
%A Stephanie Goldby
%A Jacqui Troughton
%A Thomas Yates
%A Alastair Gray
%A Melanie J Davies
%A for the LetĄ¯s Prevent Collaborators
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-56
%X Cluster randomised controlled trial undertaken at the level of primary care practices. Follow-up will be conducted at 12, 24 and 36 months. The primary outcome is the incidence of type 2 diabetes. Secondary outcomes include changes in HbA1c, blood glucose levels, cardiovascular risk, the presence of the Metabolic Syndrome and the cost-effectiveness of the intervention.The study consists of screening and intervention phases within 44 general practices coordinated from a single academic research centre. Those at high risk of impaired glucose regulation or type 2 diabetes are identified using a risk score and invited for screening using a 75 g-oral glucose tolerance test. Those with screen detected impaired glucose regulation will be invited to take part in the trial. Practices will be randomised to standard care or the intensive arm. Participants from intensive arm practices will receive a structured education programme with motivational maintenance via the telephone and annual refresher sessions. The study will run from 2009¨C2014.This study will provide new evidence surrounding the long-term effectiveness of a diabetes prevention programme conducted within routine primary care in the United Kingdom.Clinicaltrials.gov NCT00677937Type 2 diabetes mellitus (T2DM) represents one of the greatest global public health challenges in the 21st century [1]. High glucose levels are currently recognised as the third leading cause of mortality globally and treatment accounts for 7-14% of total health care spending across all global regions [2,3]. International and national health care organisations have responded to this urgent health care need by focusing on recommendations and policy aimed at prevention. In the United Kingdom, this has taken the form of the NHS Health Checks programme which is aimed at screening all individuals between 40 to 75 years of age for vascular and metabolic disease risk and then treating high risk individuals accordingly [4]. Preventing T2DM is one of t
%K Type 2 diabetes
%K Prevention
%K Impaired glucose regulation
%K Cluster randomised controlled trial
%K Screening
%U http://www.cardiab.com/content/11/1/56