%0 Journal Article
%T Reduced lung function is independently associated with increased risk of type 2 diabetes in Korean men
%A Chang-Hee Kwon
%A Eun-Jung Rhee
%A Jae-Uk Song
%A Jung-Tae Kim
%A Hyon Joo Kwag
%A Ki-Chul Sung
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-38
%X This study included 9,220 men (mean age: 41.4£¿years) without type 2 diabetes at baseline who were followed for five years. Subjects were divided into four groups according to baseline forced vital capacity (FVC) (% predicted) and forced expiratory volume in one second (FEV1) (% predicted) quartiles. The incidence of type 2 diabetes at follow-up was compared according to FVC and FEV1 quartiles.The overall incidence of type 2 diabetes was 2.2%. Reduced lung function was significantly associated with the incidence of type 2 diabetes after adjusting for age, BMI, education, smoking, exercise, alcohol, and HOMA-IR. Both FVC and FEV1 were negatively associated with type 2 diabetes (P£¿<£¿0.05). In non-obese subjects with BMI£¿<£¿25, the lowest quartile of FVC and FEV1 had a significantly higher odds ratio for type 2 diabetes compared with the highest quartile after adjusting for age and BMI (2.15 [95% CI 1.02-4.57] and 2.19 [95% CI 1.09-4.42]).Reduced lung function is independently associated with the incidence of type 2 diabetes in Korean men.Obesity is a serious problem that causes various metabolic diseases [1,2]. Type 2 diabetes is a representative metabolic diseases that is caused by obesity, and recent survey presents rapidly increasing prevalence of diabetes in Koreans [3].The association between obesity and respiratory dysfunction is as old as recorded history [4], and obstructive sleep apnea could be the link that associates obesity with reduced lung function [5]. In a very recent study by Fredheim et al. [6] showed direct associations of prediabetes and type 2 diabetes with obstructive sleep apnea in extremely obese subjects, suggesting possible link between sleep apnea, reduced lung function and glucose intolerance. From the above algorithm, reduced lung function as measured by forced vital capacity (FVC) or forced expiratory volume in one second (FEV1) could be suggested as the predictor for type 2 diabetes development [7-11]. These studies suggest that lung dysfu
%K Lung function
%K Type 2 diabetes mellitus
%K Retrospective study
%U http://www.cardiab.com/content/11/1/38