%0 Journal Article
%T Gender difference in carotid intima-media thickness in type 2 diabetic patients: a 4-year follow-up study
%A Bo Zhao
%A Yanping Liu
%A Yifei Zhang
%A Yuhong Chen
%A Zhifang Yang
%A Ying Zhu
%A Weiwei Zhan
%J Cardiovascular Diabetology
%D 2012
%I BioMed Central
%R 10.1186/1475-2840-11-51
%X 355 T2DM patients (mean age 59£¿years; 54.9% women) were included in the present study. CIMT were measured using Color Doppler ultrasound. CIMT was measured at baseline (CIMT) in 2006 and at follow-up in 2010. Biochemical and clinical measurements were collected at baseline.Mean value of CIMT1 and CIMT2 were 0.740£¿¡À£¿0.148£¿mm and 0.842£¿¡À£¿0.179£¿mm, respectively. Men had higher CIMT than women both at baseline and at follow-up (CIMT1: 0.762£¿¡À£¿0.149 vs 0.723£¿¡À£¿0.146£¿mm, P£¿=£¿0.0149; CIMT2: 0.880£¿¡À£¿0.189 vs 0.810£¿¡À£¿0.164£¿mm, P£¿=£¿0.0002). Mean annual progression of CIMT (dCIMT) was 0.025£¿¡À£¿0.022£¿mm/year. dCIMT was larger in men than in women (0.030£¿¡À£¿0.025 vs 0.022£¿¡À£¿0.019£¿mm, P£¿=£¿0.0006). In multiple regression analyses, age was an independent risk factor of CIMT in both genders, while dCIMT was associated with age only in men.Gender difference in CIMT was confirmed in T2DM patients. Moreover, impact of ageing on CIMT progression only existed in men, which might be the reason that gender difference in CIMT increased with age.Patients with type 2 diabetes mellitus (T2DM) have 2¨C6 fold higher risk of cardiovascular disease (CVD) than non-diabetics [1], which accounts for nearly 50% diabetes-related mortality [2]. Carotid intima-media thickness (CIMT) measured by ultrasound has been proved to be an independent risk factor of CVD [3,4]. It is suitable for large population study, because this measurement is non-invasive, low-cost and convenient. Moreover, CIMT has been used in clinical trials to evaluate the efficacy of anti-diabetic, anti-hyperlipidemia and anti-hypertensive treatments [5-8].Cross-sectional population studies have demonstrated that men usually have higher CIMT than women of similar age [9-11]. However, gender difference in CIMT has been seldom studied in longitudinal studies, especially in T2DM patients [12-17].Therefore, we prospectively analyzed CIMT in T2DM patients over a 4-year follow-up period in aim to investigate gender difference in CIMT and to track
%K Type 2 diabetes mellitus
%K Intima-media thickness
%K Gender difference
%U http://www.cardiab.com/content/11/1/51